Cichorium intybus L. Hairy Roots as a Platform for Antimicrobial Activity

Suvi T. Häkkinen; Katarina Cankar; Liisa Nohynek; Jeroen van Arkel; Markus Laurel; Kirsi Marja Oksman-Caldentey; Bart Van Droogenbroeck

doi:10.3390/ph16020140

Cichorium intybus L. Hairy Roots as a Platform for Antimicrobial Activity

Suvi T. Häkkinen^*, Katarina Cankar, Liisa Nohynek, Jeroen van Arkel, Markus Laurel, Kirsi Marja Oksman-Caldentey, Bart Van Droogenbroeck

^*Corresponding author for this work

BIOS Applied Metabolic Systems

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Industrial chicory is an important crop for its high dietary fibre content. Besides inulin, chicory taproots contain interesting secondary metabolite compounds, which possess bioactive properties. Hairy roots are differentiated plant cell cultures that have shown to be feasible biotechnological hosts for the production of several plant-derived molecules. In this study, hairy roots of industrial chicory cultivars were established, and their potential as a source of antimicrobial ingredients was assessed. It was shown that hot water extracts of hairy roots possessed antimicrobial activity against relevant human microbes, whereas corresponding chicory taproots did not show activity. Remarkably, a significant antimicrobial activity of hot water extracts of chicory hairy roots towards methicillin-resistant Staphylococcus aureus was observed, indicating a high potential of hairy roots as a host for production of antimicrobial agents.

Original language	English
Article number	140
Journal	Pharmaceuticals
Volume	16
Issue number	2
DOIs	https://doi.org/10.3390/ph16020140
Publication status	Published - Feb 2023

Keywords

antimicrobial activity
chicory
hairy roots
MRSA
polyphenols
sesquiterpenes

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10.3390/ph16020140Licence: CC BY

https://edepot.wur.nl/589576Licence: CC BY

Cite this

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title = "Cichorium intybus L. Hairy Roots as a Platform for Antimicrobial Activity",

abstract = "Industrial chicory is an important crop for its high dietary fibre content. Besides inulin, chicory taproots contain interesting secondary metabolite compounds, which possess bioactive properties. Hairy roots are differentiated plant cell cultures that have shown to be feasible biotechnological hosts for the production of several plant-derived molecules. In this study, hairy roots of industrial chicory cultivars were established, and their potential as a source of antimicrobial ingredients was assessed. It was shown that hot water extracts of hairy roots possessed antimicrobial activity against relevant human microbes, whereas corresponding chicory taproots did not show activity. Remarkably, a significant antimicrobial activity of hot water extracts of chicory hairy roots towards methicillin-resistant Staphylococcus aureus was observed, indicating a high potential of hairy roots as a host for production of antimicrobial agents.",

keywords = "antimicrobial activity, chicory, hairy roots, MRSA, polyphenols, sesquiterpenes",

author = "H{\"a}kkinen, {Suvi T.} and Katarina Cankar and Liisa Nohynek and {van Arkel}, Jeroen and Markus Laurel and Oksman-Caldentey, {Kirsi Marja} and {Van Droogenbroeck}, Bart",

year = "2023",

month = feb,

doi = "10.3390/ph16020140",

language = "English",

volume = "16",

journal = "Pharmaceuticals",

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TY - JOUR

T1 - Cichorium intybus L. Hairy Roots as a Platform for Antimicrobial Activity

AU - Häkkinen, Suvi T.

AU - Cankar, Katarina

AU - Nohynek, Liisa

AU - van Arkel, Jeroen

AU - Laurel, Markus

AU - Oksman-Caldentey, Kirsi Marja

AU - Van Droogenbroeck, Bart

PY - 2023/2

Y1 - 2023/2

N2 - Industrial chicory is an important crop for its high dietary fibre content. Besides inulin, chicory taproots contain interesting secondary metabolite compounds, which possess bioactive properties. Hairy roots are differentiated plant cell cultures that have shown to be feasible biotechnological hosts for the production of several plant-derived molecules. In this study, hairy roots of industrial chicory cultivars were established, and their potential as a source of antimicrobial ingredients was assessed. It was shown that hot water extracts of hairy roots possessed antimicrobial activity against relevant human microbes, whereas corresponding chicory taproots did not show activity. Remarkably, a significant antimicrobial activity of hot water extracts of chicory hairy roots towards methicillin-resistant Staphylococcus aureus was observed, indicating a high potential of hairy roots as a host for production of antimicrobial agents.

AB - Industrial chicory is an important crop for its high dietary fibre content. Besides inulin, chicory taproots contain interesting secondary metabolite compounds, which possess bioactive properties. Hairy roots are differentiated plant cell cultures that have shown to be feasible biotechnological hosts for the production of several plant-derived molecules. In this study, hairy roots of industrial chicory cultivars were established, and their potential as a source of antimicrobial ingredients was assessed. It was shown that hot water extracts of hairy roots possessed antimicrobial activity against relevant human microbes, whereas corresponding chicory taproots did not show activity. Remarkably, a significant antimicrobial activity of hot water extracts of chicory hairy roots towards methicillin-resistant Staphylococcus aureus was observed, indicating a high potential of hairy roots as a host for production of antimicrobial agents.

KW - antimicrobial activity

KW - chicory

KW - hairy roots

KW - MRSA

KW - polyphenols

KW - sesquiterpenes

U2 - 10.3390/ph16020140

DO - 10.3390/ph16020140

M3 - Article

AN - SCOPUS:85148945496

SN - 1424-8247

VL - 16

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 2

M1 - 140

ER -

Cichorium intybus L. Hairy Roots as a Platform for Antimicrobial Activity

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Keywords

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