Chronic quercetin exposure affects fatty acid catabolism in rat lung

V.C.J. de Boer, E.M. van Schothorst, A.A. Dihal, H. van der Woude, I.C.W. Arts, I.M.C.M. Rietjens, P.C.H. Hollman, J. Keijer

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)

Abstract

Dietary quercetin intake is suggested to be health promoting, but this assumption is mainly based on mechanistic studies performed in vitro. Previously, we identified rat lung as a quercetin target tissue. To assess relevant in vivo health effects of quercetin, we analyzed mechanisms of effect in rat lungs of a chronic (41 weeks) 1% quercetin diet using whole genome microarrays. We show here that fatty acid catabolism pathways, like beta-oxidation and ketogenesis, are up-regulated by Dietary quercetin intake is suggested to be health promoting, but this assumption is mainly based on mechanistic studies performed in vitro. Previously, we identified rat lung as a quercetin target tissue. To assess relevant in vivo health effects of quercetin, we analyzed mechanisms of effect in rat lungs of a chronic (41 weeks) 1% quercetin diet using whole genome microarrays. We show here that fatty acid catabolism pathways, like beta-oxidation and ketogenesis, are up-regulated by the long-term quercetin intervention. Up-regulation of genes (Hmgcs2, Ech1, Acox1, Pcca, Lpl and Acaa2) was verified and confirmed by quantitative real time PCR. In addition, free fatty acid levels were decreased in rats fed the quercetin diet, confirming that quercetin affects fatty acid catabolism. This in vivo study demonstrates for the first time that fatty acid catabolism is a relevant process that is affected in rats by chronic dietary quercetin
Original languageEnglish
Pages (from-to)2847-2858
JournalCellular and Molecular Life Sciences
Volume63
Issue number23
DOIs
Publication statusPublished - 2006

Keywords

  • dependent anion channel
  • diet-induced obesity
  • colon-cancer cells
  • gene-expression
  • dna microarray
  • green tea
  • in-vitro
  • polyphenols
  • inhibition
  • mice

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