Choline Intake, Plasma Riboflavin, and the Phosphatidylethanolamine N-Methyltransferase G5465A Genotype Predict Plasma Homocysteine in Folate-Deplete Mexican-American Men with the Methylenetetrahydrofolate Reductase 677TT Genotype

M.A. Caudill, N. Dellschaft, C. Solis, S. Hinkis, A.A. Ivanov, S. Nash-Barboza, K.E. Randall, B. Jackson, G.N. Solomita, F. Vermeylen

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Abstract

We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype. However, the substantial variation in tHcy within the 677TT genotype at wk 12 implied that several factors were interacting with this genotype to affect homocysteine. As an extension of this work, the present study sought to identify the main predictors of wk-12 plasma tHcy, alone and together with the MTHFR C677T genotype (29 TT, 31 CC), using linear regression analysis. A basic model explaining 82.5% of the variation (i.e. adjusted R-2 =0.825) was constructed. However, the effects of the variables within this model were dependent upon the MTHFR C677T genotype (P for interaction A variant predicted lower tHcy (P
Original languageEnglish
Pages (from-to)727-733
JournalThe Journal of Nutrition
Volume139
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • liquid-chromatography
  • mass-spectrometry
  • common mutation
  • methyl balance
  • young-women
  • polymorphism
  • metabolism
  • disease
  • humans
  • serum

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