Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci

J.J. Fros, N.E. Domeradzka, J. Baggen, C. Geertsema, J. Flipse, J.M. Vlak, G.P. Pijlman

Research output: Contribution to journalArticleAcademicpeer-review

87 Citations (Scopus)

Abstract

Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci. A conserved SH3 domain-binding motif in nsP3 is essential for both nsP3-G3BP interactions and viral RNA replication. This study reveals a novel role for nsP3 as a regulator of the cellular stress response
Original languageEnglish
Pages (from-to)10873-10879
JournalJournal of Virology
Volume86
Issue number19
DOIs
Publication statusPublished - 2012

Keywords

  • sindbis virus
  • infected-cells
  • phosphorylation
  • translation
  • complexes
  • region

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