Characterization of the innate and adaptive immunity to Salmonella enteritidis PT1 infection in four broiler lines

J. Kramer, A.H. Visscher, J.A. Wagenaar, A.G. Boonstra Blom, S.H. Jeurissen

    Research output: Contribution to journalArticleAcademicpeer-review

    28 Citations (Scopus)

    Abstract

    Four broiler lines were inoculated orally with Salmonella enteritidis phage type 1 at the age of 7 days (experiment A: lines 1 and 2) and at the age of 1 day (experiment B: lines 3 and 4). At various days post-infection chickens were sacrificed and the number of Salmonella in the caeca, liver, and spleen were determined. Furthermore, phagocytic activity, cellular immune responses, and humoral responses were determined using, respectively, single-cell suspensions of spleen or intestine and serum. In both experiments, similar trends were seen. Increased numbers of S. enteritidis were found in the caeca of lines 1 and 3, whereas at the same time a decreased colonization was found in the spleen and in the liver, as compared to lines 2 and 4. In the latter two lines, the phagocytic activity of the phagocytes was higher and the humoral responses were lower. Observations from this study suggest that lower activity of phagocytes and higher humoral activity prevent systemic S. enteritidis infection. Copyright
    Original languageEnglish
    Pages (from-to)219-233
    JournalVeterinary Immunology and Immunopathology
    Volume79
    Issue number3-4
    DOIs
    Publication statusPublished - 2001

    Fingerprint

    Salmonella enteritidis
    Adaptive Immunity
    Salmonella Enteritidis
    Innate Immunity
    spleen
    Spleen
    broiler chickens
    phagocytes
    Phagocytes
    phagocytosis
    humoral immunity
    cecum
    Infection
    Salmonella Phages
    infection
    liver
    Salmonella Infections
    Liver
    Cellular Immunity
    Salmonella

    Cite this

    Kramer, J. ; Visscher, A.H. ; Wagenaar, J.A. ; Boonstra Blom, A.G. ; Jeurissen, S.H. / Characterization of the innate and adaptive immunity to Salmonella enteritidis PT1 infection in four broiler lines. In: Veterinary Immunology and Immunopathology. 2001 ; Vol. 79, No. 3-4. pp. 219-233.
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    title = "Characterization of the innate and adaptive immunity to Salmonella enteritidis PT1 infection in four broiler lines",
    abstract = "Four broiler lines were inoculated orally with Salmonella enteritidis phage type 1 at the age of 7 days (experiment A: lines 1 and 2) and at the age of 1 day (experiment B: lines 3 and 4). At various days post-infection chickens were sacrificed and the number of Salmonella in the caeca, liver, and spleen were determined. Furthermore, phagocytic activity, cellular immune responses, and humoral responses were determined using, respectively, single-cell suspensions of spleen or intestine and serum. In both experiments, similar trends were seen. Increased numbers of S. enteritidis were found in the caeca of lines 1 and 3, whereas at the same time a decreased colonization was found in the spleen and in the liver, as compared to lines 2 and 4. In the latter two lines, the phagocytic activity of the phagocytes was higher and the humoral responses were lower. Observations from this study suggest that lower activity of phagocytes and higher humoral activity prevent systemic S. enteritidis infection. Copyright",
    author = "J. Kramer and A.H. Visscher and J.A. Wagenaar and {Boonstra Blom}, A.G. and S.H. Jeurissen",
    year = "2001",
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    Characterization of the innate and adaptive immunity to Salmonella enteritidis PT1 infection in four broiler lines. / Kramer, J.; Visscher, A.H.; Wagenaar, J.A.; Boonstra Blom, A.G.; Jeurissen, S.H.

    In: Veterinary Immunology and Immunopathology, Vol. 79, No. 3-4, 2001, p. 219-233.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Characterization of the innate and adaptive immunity to Salmonella enteritidis PT1 infection in four broiler lines

    AU - Kramer, J.

    AU - Visscher, A.H.

    AU - Wagenaar, J.A.

    AU - Boonstra Blom, A.G.

    AU - Jeurissen, S.H.

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    AB - Four broiler lines were inoculated orally with Salmonella enteritidis phage type 1 at the age of 7 days (experiment A: lines 1 and 2) and at the age of 1 day (experiment B: lines 3 and 4). At various days post-infection chickens were sacrificed and the number of Salmonella in the caeca, liver, and spleen were determined. Furthermore, phagocytic activity, cellular immune responses, and humoral responses were determined using, respectively, single-cell suspensions of spleen or intestine and serum. In both experiments, similar trends were seen. Increased numbers of S. enteritidis were found in the caeca of lines 1 and 3, whereas at the same time a decreased colonization was found in the spleen and in the liver, as compared to lines 2 and 4. In the latter two lines, the phagocytic activity of the phagocytes was higher and the humoral responses were lower. Observations from this study suggest that lower activity of phagocytes and higher humoral activity prevent systemic S. enteritidis infection. Copyright

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    JO - Veterinary Immunology and Immunopathology

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