Changes in ventilation and locomotion of Gammarus pulex (Crustacea, Amphipoda) in response to low concentrations of pharmaceuticals

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Abstract

Exposure to contaminants below lethal concentrations may affect the performance of organisms, resulting in measurable differences in behavior. We measured the response of the benthic invertebrate Gammarus pulex (Crustacea, Amphipoda) to sublethal concentrations of three pharmaceuticals, fluoxetine, ibuprofen and carbamazepine, and the cationic surfactant cetyltrimethylammonium bromide (CTAB). Responses in behavior during exposure were analyzed using the multivariate method of Principal Response Curves (PRC). The PRC results show that exposure to low pharmaceutical concentrations (range 1-100 ng/l) resulted in increased ventilation, whereas exposure to control or to high concentrations (1 ¿ g/l-1 mg/L) resulted in increased locomotion. Exposure to CTAB resulted in decreased locomotion and increased ventilation at increasing concentrations. The results of our experiments indicate that increased ventilation can be used as a general sign of stress, but not necessarily an early warning signal for mortality.
Original languageEnglish
Pages (from-to)111-120
JournalHuman and Ecological Risk Assessment
Volume15
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Amphipoda
Crustacea
locomotion
Locomotion
Drug products
Ventilation
ventilation
drug
Pharmaceutical Preparations
bromide
Fluoxetine
Ibuprofen
Cationic surfactants
Carbamazepine
Invertebrates
Surface-Active Agents
Impurities
Mortality
surfactant
invertebrate

Keywords

  • sewage-treatment plants
  • fresh-water biomonitor
  • acid-mine drainage
  • behavioral-responses
  • impedance conversion
  • oncorhynchus-mykiss
  • surface waters
  • waste-water
  • toxicity
  • exposure

Cite this

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title = "Changes in ventilation and locomotion of Gammarus pulex (Crustacea, Amphipoda) in response to low concentrations of pharmaceuticals",
abstract = "Exposure to contaminants below lethal concentrations may affect the performance of organisms, resulting in measurable differences in behavior. We measured the response of the benthic invertebrate Gammarus pulex (Crustacea, Amphipoda) to sublethal concentrations of three pharmaceuticals, fluoxetine, ibuprofen and carbamazepine, and the cationic surfactant cetyltrimethylammonium bromide (CTAB). Responses in behavior during exposure were analyzed using the multivariate method of Principal Response Curves (PRC). The PRC results show that exposure to low pharmaceutical concentrations (range 1-100 ng/l) resulted in increased ventilation, whereas exposure to control or to high concentrations (1 ¿ g/l-1 mg/L) resulted in increased locomotion. Exposure to CTAB resulted in decreased locomotion and increased ventilation at increasing concentrations. The results of our experiments indicate that increased ventilation can be used as a general sign of stress, but not necessarily an early warning signal for mortality.",
keywords = "sewage-treatment plants, fresh-water biomonitor, acid-mine drainage, behavioral-responses, impedance conversion, oncorhynchus-mykiss, surface waters, waste-water, toxicity, exposure",
author = "{de Lange}, H.J. and E.T.H.M. Peeters and M.F.L.L.W. L{\"u}rling",
year = "2009",
doi = "10.1080/10807030802615584",
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journal = "Human and Ecological Risk Assessment",
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TY - JOUR

T1 - Changes in ventilation and locomotion of Gammarus pulex (Crustacea, Amphipoda) in response to low concentrations of pharmaceuticals

AU - de Lange, H.J.

AU - Peeters, E.T.H.M.

AU - Lürling, M.F.L.L.W.

PY - 2009

Y1 - 2009

N2 - Exposure to contaminants below lethal concentrations may affect the performance of organisms, resulting in measurable differences in behavior. We measured the response of the benthic invertebrate Gammarus pulex (Crustacea, Amphipoda) to sublethal concentrations of three pharmaceuticals, fluoxetine, ibuprofen and carbamazepine, and the cationic surfactant cetyltrimethylammonium bromide (CTAB). Responses in behavior during exposure were analyzed using the multivariate method of Principal Response Curves (PRC). The PRC results show that exposure to low pharmaceutical concentrations (range 1-100 ng/l) resulted in increased ventilation, whereas exposure to control or to high concentrations (1 ¿ g/l-1 mg/L) resulted in increased locomotion. Exposure to CTAB resulted in decreased locomotion and increased ventilation at increasing concentrations. The results of our experiments indicate that increased ventilation can be used as a general sign of stress, but not necessarily an early warning signal for mortality.

AB - Exposure to contaminants below lethal concentrations may affect the performance of organisms, resulting in measurable differences in behavior. We measured the response of the benthic invertebrate Gammarus pulex (Crustacea, Amphipoda) to sublethal concentrations of three pharmaceuticals, fluoxetine, ibuprofen and carbamazepine, and the cationic surfactant cetyltrimethylammonium bromide (CTAB). Responses in behavior during exposure were analyzed using the multivariate method of Principal Response Curves (PRC). The PRC results show that exposure to low pharmaceutical concentrations (range 1-100 ng/l) resulted in increased ventilation, whereas exposure to control or to high concentrations (1 ¿ g/l-1 mg/L) resulted in increased locomotion. Exposure to CTAB resulted in decreased locomotion and increased ventilation at increasing concentrations. The results of our experiments indicate that increased ventilation can be used as a general sign of stress, but not necessarily an early warning signal for mortality.

KW - sewage-treatment plants

KW - fresh-water biomonitor

KW - acid-mine drainage

KW - behavioral-responses

KW - impedance conversion

KW - oncorhynchus-mykiss

KW - surface waters

KW - waste-water

KW - toxicity

KW - exposure

U2 - 10.1080/10807030802615584

DO - 10.1080/10807030802615584

M3 - Article

VL - 15

SP - 111

EP - 120

JO - Human and Ecological Risk Assessment

JF - Human and Ecological Risk Assessment

SN - 1080-7039

IS - 1

ER -