Changes in transferrin are related to changes in insulin resistance: the SLIM study

C. Roumen, E.J.M. Feskens, E.H. Jansen, W.H. Saris, E.E. Blaak

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Aims To determine the effect of a lifestyle intervention on serum transferrin and ferritin levels and the relationship between changes in transferrin and ferritin and changes in glucose tolerance and insulin resistance. Methods Randomized controlled lifestyle intervention directed at a healthy diet and increased physical activity in subjects with impaired glucose tolerance. Results After 1 year, the change in ferritin levels in the intervention group as compared with the control group did not reach statistical significance (P = 0.06). Transferrin change was independently related to the change in homeostasis model assessment of insulin resistance and ferritin change was related to the change in 2-h free fatty acids. Conclusions Changes in insulin sensitivity and postprandial lipid metabolism are related to changes in iron metabolism.
Original languageEnglish
Pages (from-to)1478-1482
JournalDiabetic medicine
Volume25
Issue number12
DOIs
Publication statusPublished - 2008

Keywords

  • metabolic syndrome
  • serum ferritin
  • glucose
  • onset

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