Changes in estrogen-alpha receptor immunoreactivity during estrous cycling in lactating dairy cattle

F.J.C.M. van Eerdenburg, I.J.J.M. Daemen, E.M. van der Beek, F.W. van Leeuwen

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

Estradiol is one of the most important hormones in the regulation of estrous behavior, which is at a very low level of expression in the modern dairy cow. In the present study the neuroanatomical distribution of estrogen receptors of the -subtype (ER-) in the bovine hypothalamic area is determined with immunocytochemical methods, at various stages of the estrous cycle. During the luteal phase of the cycle, ER- immunoreactive cells were found in most of the nuclei that are known to express ER- immunoreactivity in other species, like the Bed nucleus of the Stria terminalis, Medial preoptic area, Ventromedial hypothalamus and Arcuate nucleus. During estrus and metestrus, however, no ER- immunoreactive cells could be detected in those areas, except for a few in the caudal Arcuate nucleus. The results from the present study indicate that there is a coherent regulation and timing of physiological and behavioral events around ovulation, in which estradiol and its receptor play a key role.
Original languageEnglish
Pages (from-to)219-223
JournalBrain Research
Volume880
DOIs
Publication statusPublished - 2000

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