CD36 deficiency protects against malarial anaemia in children by reducing Plasmodium falciparum-infected red blood cell adherence to vascular endothelium

J. Chilongola, S.T. Balthazary, M. Mpina, M. Mhando, E.V. Mbugi

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Objective CD36 is a receptor that occurs on the surface of activated immune cells, vascular endothelial cells and participates in phagocytosis and lipid metabolism. CD36 is known to be the major endothelial receptor molecule for field isolates of Plasmodium falciparum. A T1264G mutation in exon X of the gene leads to deficiency of CD36. This study aimed at determining associations between CD36 deficiency, P. falciparum in vitro adherence on purified CD36 and anaemia among children in an endemic area. Methods Genotypes were determined by nested polymerase chain reaction of isolated DNA from filter blood spots followed by Restriction Fragment Length Polymorphism (RFLP). Plasmodium falciparum adherence assays were performed on immobilized purified CD36. Results The data indicate that CD36 is an important cytoadherence receptor that mediates adherence to most P. falciparum field isolates. Our findings also suggest that mutations causing CD36 deficiency may confer significant protection against malarial anaemia (MA) in children (¿2 = 8.58, P <0.01). Conclusion That the protective role that CD36 deficiency may confer against MA in children seems to be mediated through reduced cytoadherence of infected red blood cells to vascular endothelium
Original languageEnglish
Pages (from-to)810-816
JournalTropical Medicine and International Health
Volume14
Issue number7
DOIs
Publication statusPublished - 2009

Keywords

  • parasitized erythrocytes
  • fatty-acid
  • cytoadherence characteristics
  • uncomplicated malaria
  • lipid-metabolism
  • receptors
  • icam-1
  • roles
  • gene
  • expression

Fingerprint Dive into the research topics of 'CD36 deficiency protects against malarial anaemia in children by reducing Plasmodium falciparum-infected red blood cell adherence to vascular endothelium'. Together they form a unique fingerprint.

  • Cite this