Case studies on genetically modified organisms (GMOs)

Potential risk scenarios and associated health indicators

Barbara De Santis*, Norbert Stockhofe, Jean Michel Wal, Eefke Weesendorp, Jean Paul Lallès, Jeroen van Dijk, Esther Kok, Marzia De Giacomo, Ralf Einspanier, Roberta Onori, Carlo Brera, Paul Bikker, Jan van der Meulen, Gijs Kleter

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Within the frame of the EU-funded MARLON project, background data were reviewed to explore the possibility of measuring health indicators during post-market monitoring for potential effects of feeds, particularly genetically modified (GM) feeds, on livestock animal health, if applicable. Four case studies (CSs) of potential health effects on livestock were framed and the current knowledge of a possible effect of GM feed was reviewed. Concerning allergenicity (CS-1), there are no case-reports of allergic reactions or immunotoxic effects resulting from GM feed consumption as compared with non-GM feed. The likelihood of horizontal gene transfer (HGT; CS-2) of GMO-related DNA to different species is not different from that for other DNA and is unlikely to raise health concerns. Concerning mycotoxins (CS-3), insect-resistant GM maize may reduce fumonisins contamination as a health benefit, yet other Fusarium toxins and aflatoxins show inconclusive results. For nutritionally altered crops (CS-4), the genetic modifications applied lead to compositional changes which require special considerations of their nutritional impacts.No health indicators were thus identified except for possible beneficial impacts of reduced mycotoxins and nutritional enhancement. More generally, veterinary health data should ideally be linked with animal exposure information so as to be able to establish cause-effect relationships.
Original languageEnglish
Pages (from-to)36-65
JournalFood and Chemical Toxicology
Volume117
Early online date30 Aug 2017
DOIs
Publication statusPublished - Jul 2018

Fingerprint

Genetically Modified Organisms
Health
genetically modified organisms
case studies
Mycotoxins
Livestock
mycotoxins
Farms
livestock
Animals
Fumonisins
Horizontal Gene Transfer
allergenicity
Aflatoxins
Gene transfer
fumonisins
DNA
Fusarium
Insurance Benefits
genetic engineering

Keywords

  • Allergenicity
  • Genetically modified -feed
  • Health indicators
  • Horizontal gene transfer
  • Mycotoxin-reduction
  • Nutritionally altered geneticalli modified crops

Cite this

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title = "Case studies on genetically modified organisms (GMOs): Potential risk scenarios and associated health indicators",
abstract = "Within the frame of the EU-funded MARLON project, background data were reviewed to explore the possibility of measuring health indicators during post-market monitoring for potential effects of feeds, particularly genetically modified (GM) feeds, on livestock animal health, if applicable. Four case studies (CSs) of potential health effects on livestock were framed and the current knowledge of a possible effect of GM feed was reviewed. Concerning allergenicity (CS-1), there are no case-reports of allergic reactions or immunotoxic effects resulting from GM feed consumption as compared with non-GM feed. The likelihood of horizontal gene transfer (HGT; CS-2) of GMO-related DNA to different species is not different from that for other DNA and is unlikely to raise health concerns. Concerning mycotoxins (CS-3), insect-resistant GM maize may reduce fumonisins contamination as a health benefit, yet other Fusarium toxins and aflatoxins show inconclusive results. For nutritionally altered crops (CS-4), the genetic modifications applied lead to compositional changes which require special considerations of their nutritional impacts.No health indicators were thus identified except for possible beneficial impacts of reduced mycotoxins and nutritional enhancement. More generally, veterinary health data should ideally be linked with animal exposure information so as to be able to establish cause-effect relationships.",
keywords = "Allergenicity, Genetically modified -feed, Health indicators, Horizontal gene transfer, Mycotoxin-reduction, Nutritionally altered geneticalli modified crops",
author = "{De Santis}, Barbara and Norbert Stockhofe and Wal, {Jean Michel} and Eefke Weesendorp and Lall{\`e}s, {Jean Paul} and {van Dijk}, Jeroen and Esther Kok and {De Giacomo}, Marzia and Ralf Einspanier and Roberta Onori and Carlo Brera and Paul Bikker and {van der Meulen}, Jan and Gijs Kleter",
year = "2018",
month = "7",
doi = "10.1016/j.fct.2017.08.033",
language = "English",
volume = "117",
pages = "36--65",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier",

}

Case studies on genetically modified organisms (GMOs) : Potential risk scenarios and associated health indicators. / De Santis, Barbara; Stockhofe, Norbert; Wal, Jean Michel; Weesendorp, Eefke; Lallès, Jean Paul; van Dijk, Jeroen; Kok, Esther; De Giacomo, Marzia; Einspanier, Ralf; Onori, Roberta; Brera, Carlo; Bikker, Paul; van der Meulen, Jan; Kleter, Gijs.

In: Food and Chemical Toxicology, Vol. 117, 07.2018, p. 36-65.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Case studies on genetically modified organisms (GMOs)

T2 - Potential risk scenarios and associated health indicators

AU - De Santis, Barbara

AU - Stockhofe, Norbert

AU - Wal, Jean Michel

AU - Weesendorp, Eefke

AU - Lallès, Jean Paul

AU - van Dijk, Jeroen

AU - Kok, Esther

AU - De Giacomo, Marzia

AU - Einspanier, Ralf

AU - Onori, Roberta

AU - Brera, Carlo

AU - Bikker, Paul

AU - van der Meulen, Jan

AU - Kleter, Gijs

PY - 2018/7

Y1 - 2018/7

N2 - Within the frame of the EU-funded MARLON project, background data were reviewed to explore the possibility of measuring health indicators during post-market monitoring for potential effects of feeds, particularly genetically modified (GM) feeds, on livestock animal health, if applicable. Four case studies (CSs) of potential health effects on livestock were framed and the current knowledge of a possible effect of GM feed was reviewed. Concerning allergenicity (CS-1), there are no case-reports of allergic reactions or immunotoxic effects resulting from GM feed consumption as compared with non-GM feed. The likelihood of horizontal gene transfer (HGT; CS-2) of GMO-related DNA to different species is not different from that for other DNA and is unlikely to raise health concerns. Concerning mycotoxins (CS-3), insect-resistant GM maize may reduce fumonisins contamination as a health benefit, yet other Fusarium toxins and aflatoxins show inconclusive results. For nutritionally altered crops (CS-4), the genetic modifications applied lead to compositional changes which require special considerations of their nutritional impacts.No health indicators were thus identified except for possible beneficial impacts of reduced mycotoxins and nutritional enhancement. More generally, veterinary health data should ideally be linked with animal exposure information so as to be able to establish cause-effect relationships.

AB - Within the frame of the EU-funded MARLON project, background data were reviewed to explore the possibility of measuring health indicators during post-market monitoring for potential effects of feeds, particularly genetically modified (GM) feeds, on livestock animal health, if applicable. Four case studies (CSs) of potential health effects on livestock were framed and the current knowledge of a possible effect of GM feed was reviewed. Concerning allergenicity (CS-1), there are no case-reports of allergic reactions or immunotoxic effects resulting from GM feed consumption as compared with non-GM feed. The likelihood of horizontal gene transfer (HGT; CS-2) of GMO-related DNA to different species is not different from that for other DNA and is unlikely to raise health concerns. Concerning mycotoxins (CS-3), insect-resistant GM maize may reduce fumonisins contamination as a health benefit, yet other Fusarium toxins and aflatoxins show inconclusive results. For nutritionally altered crops (CS-4), the genetic modifications applied lead to compositional changes which require special considerations of their nutritional impacts.No health indicators were thus identified except for possible beneficial impacts of reduced mycotoxins and nutritional enhancement. More generally, veterinary health data should ideally be linked with animal exposure information so as to be able to establish cause-effect relationships.

KW - Allergenicity

KW - Genetically modified -feed

KW - Health indicators

KW - Horizontal gene transfer

KW - Mycotoxin-reduction

KW - Nutritionally altered geneticalli modified crops

U2 - 10.1016/j.fct.2017.08.033

DO - 10.1016/j.fct.2017.08.033

M3 - Article

VL - 117

SP - 36

EP - 65

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -