Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

Oxana Rotar; Maria Boyarinova; Ekaterina Moguchaya; Kristina Tolkunova; Nikita Kolosov; Valeriia Rezapova; Olga Freylikhman; Dmitrii Usoltsev; Olesya Melnik; Alexey Sergushichev; Vladislav Solntsev; Anna Kostareva; Elena Dubinina; Trudy Voortman; Christine Stevens; Mark J. Daly; Alexandra Konradi; Evgeny Shlyakhto; Mykyta Artomov

doi:10.3389/fcvm.2022.843439

Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

Oxana Rotar, Maria Boyarinova, Ekaterina Moguchaya, Kristina Tolkunova, Nikita Kolosov, Valeriia Rezapova, Olga Freylikhman, Dmitrii Usoltsev, Olesya Melnik, Alexey Sergushichev, Vladislav Solntsev, Anna Kostareva, Elena Dubinina, Trudy Voortman, Christine Stevens, Mark J. Daly, Alexandra Konradi, Evgeny Shlyakhto, Mykyta Artomov^*

^*Corresponding author for this work

Nutrition and Disease

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.

Original language	English
Article number	843439
Journal	Frontiers in Cardiovascular Medicine
Volume	9
DOIs	https://doi.org/10.3389/fcvm.2022.843439
Publication status	Published - 23 May 2022

Keywords

aging
deep phenotyping
pulse wave velocity (PWV)
starvation
supernormal vascular aging

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https://edepot.wur.nl/578765Licence: CC BY

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Rotar, O., Boyarinova, M., Moguchaya, E., Tolkunova, K., Kolosov, N., Rezapova, V., Freylikhman, O., Usoltsev, D., Melnik, O., Sergushichev, A., Solntsev, V., Kostareva, A., Dubinina, E., Voortman, T., Stevens, C., Daly, M. J., Konradi, A., Shlyakhto, E., & Artomov, M. (2022). Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors. Frontiers in Cardiovascular Medicine, 9, Article 843439. https://doi.org/10.3389/fcvm.2022.843439

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title = "Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors",

abstract = "Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.",

keywords = "aging, deep phenotyping, pulse wave velocity (PWV), starvation, supernormal vascular aging",

author = "Oxana Rotar and Maria Boyarinova and Ekaterina Moguchaya and Kristina Tolkunova and Nikita Kolosov and Valeriia Rezapova and Olga Freylikhman and Dmitrii Usoltsev and Olesya Melnik and Alexey Sergushichev and Vladislav Solntsev and Anna Kostareva and Elena Dubinina and Trudy Voortman and Christine Stevens and Daly, {Mark J.} and Alexandra Konradi and Evgeny Shlyakhto and Mykyta Artomov",

year = "2022",

month = may,

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doi = "10.3389/fcvm.2022.843439",

language = "English",

volume = "9",

journal = "Frontiers in Cardiovascular Medicine",

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Rotar, O, Boyarinova, M, Moguchaya, E, Tolkunova, K, Kolosov, N, Rezapova, V, Freylikhman, O, Usoltsev, D, Melnik, O, Sergushichev, A, Solntsev, V, Kostareva, A, Dubinina, E, Voortman, T, Stevens, C, Daly, MJ, Konradi, A, Shlyakhto, E & Artomov, M 2022, 'Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors', Frontiers in Cardiovascular Medicine, vol. 9, 843439. https://doi.org/10.3389/fcvm.2022.843439

TY - JOUR

T1 - Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

AU - Rotar, Oxana

AU - Boyarinova, Maria

AU - Moguchaya, Ekaterina

AU - Tolkunova, Kristina

AU - Kolosov, Nikita

AU - Rezapova, Valeriia

AU - Freylikhman, Olga

AU - Usoltsev, Dmitrii

AU - Melnik, Olesya

AU - Sergushichev, Alexey

AU - Solntsev, Vladislav

AU - Kostareva, Anna

AU - Dubinina, Elena

AU - Voortman, Trudy

AU - Stevens, Christine

AU - Daly, Mark J.

AU - Konradi, Alexandra

AU - Shlyakhto, Evgeny

AU - Artomov, Mykyta

PY - 2022/5/23

Y1 - 2022/5/23

N2 - Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.

AB - Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.

KW - aging

KW - deep phenotyping

KW - pulse wave velocity (PWV)

KW - starvation

KW - supernormal vascular aging

U2 - 10.3389/fcvm.2022.843439

DO - 10.3389/fcvm.2022.843439

M3 - Article

AN - SCOPUS:85138463996

SN - 2297-055X

VL - 9

JO - Frontiers in Cardiovascular Medicine

JF - Frontiers in Cardiovascular Medicine

M1 - 843439

ER -

Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

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Keywords

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