Abstract
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the World Congress on Genetics Applied to Livestock Production |
| Subtitle of host publication | Volume Biology - Disease Resistance 3 |
| Publisher | WCGALP |
| Number of pages | 4 |
| Publication status | Published - Feb 2018 |
| Event | 11th World Congress on Genetics Applied to Livestock Production - Auckland, New Zealand Duration: 11 Feb 2018 → 16 Feb 2018 |
Conference
| Conference | 11th World Congress on Genetics Applied to Livestock Production |
|---|---|
| Country | New Zealand |
| City | Auckland |
| Period | 11/02/18 → 16/02/18 |
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Candidate gene for natural immune competence in chickens revealed through genome wide association study. / Visker, M.H.P.W.; Berghof, T.V.L.; Arts, J.A.J.; Parmentier, H.K.; van der Poel, J.J.; Vereijken, Addie; Bovenhuis, H.
Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology - Disease Resistance 3. WCGALP, 2018. 43.Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic
TY - GEN
T1 - Candidate gene for natural immune competence in chickens revealed through genome wide association study
AU - Visker, M.H.P.W.
AU - Berghof, T.V.L.
AU - Arts, J.A.J.
AU - Parmentier, H.K.
AU - van der Poel, J.J.
AU - Vereijken, Addie
AU - Bovenhuis, H.
PY - 2018/2
Y1 - 2018/2
N2 - Natural antibodies (NAb) are antibodies that are present in individuals without prior exposure to the antigen that they bind. In chickens, NAb have been associated with survival. Furthermore, genetic variation between chickens in NAb levels has been demonstrated. To improve our understanding of the genetic variation for NAb levels in chickens we performed a genome wide association study. A population of 1,628 White Leghorn chickens was investigated. Animals were phenotyped for NAb levels using the antigen keyhole limpet hemocyanin (KLH) as model. Animals were genotyped for 15,579 single nucleotide polymorphisms (SNP). Highly significant association between SNP and NAb levels was observed on chicken chromosome 4. A single SNP was identified as the most likely candidate for this association. Identification of this candidate SNP was based on further analysis with full genome sequence genotypes and on predicted consequences of associated SNP. This candidate SNP causes a phenylalanine to leucine amino acid change in one of the leucine rich repeats in toll-like receptor 1 family member A (TLR1A). Our results suggest an important role for TLR1A in relation to NAb levels in chickens. Further study should confirm the effect of the SNP in TLR1A on NAb levels and on the (natural) immune competence of chickens. Keywords: natural antibodies, toll-like receptor, TLR1A
AB - Natural antibodies (NAb) are antibodies that are present in individuals without prior exposure to the antigen that they bind. In chickens, NAb have been associated with survival. Furthermore, genetic variation between chickens in NAb levels has been demonstrated. To improve our understanding of the genetic variation for NAb levels in chickens we performed a genome wide association study. A population of 1,628 White Leghorn chickens was investigated. Animals were phenotyped for NAb levels using the antigen keyhole limpet hemocyanin (KLH) as model. Animals were genotyped for 15,579 single nucleotide polymorphisms (SNP). Highly significant association between SNP and NAb levels was observed on chicken chromosome 4. A single SNP was identified as the most likely candidate for this association. Identification of this candidate SNP was based on further analysis with full genome sequence genotypes and on predicted consequences of associated SNP. This candidate SNP causes a phenylalanine to leucine amino acid change in one of the leucine rich repeats in toll-like receptor 1 family member A (TLR1A). Our results suggest an important role for TLR1A in relation to NAb levels in chickens. Further study should confirm the effect of the SNP in TLR1A on NAb levels and on the (natural) immune competence of chickens. Keywords: natural antibodies, toll-like receptor, TLR1A
M3 - Conference paper
BT - Proceedings of the World Congress on Genetics Applied to Livestock Production
PB - WCGALP
ER -