Candida Rugosa Lipase-catalyzed Kinetic Resolution of 3-(Isobutyryloxy)methyl 4-[2-(Difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate

A. Sobolev, R. Zhalubovskis, M.C.R. Franssen, B. Vigante, B. Chekavichus, G. Duburs, Æ. de Groot

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3 Citations (Scopus)

Abstract

The lipase-catalyzed kinetic resolution of 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate has been performed. The most enantioselective reaction (E = 28) was transesterification with n-butanol in water-saturated toluene at 45°C
Original languageEnglish
Pages (from-to)931-937
JournalChemistry of Heterocyclic Compounds
Volume40
Issue number7
DOIs
Publication statusPublished - 2004

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