Prochiral bis(ethoxycarbonylmethyl) substituted 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates were hydrolyzed enantioselectively by Candida antarctica lipase B (Novozym 435). The enantiomeric excesses varied from 68 to 93°depending on the substituent at position 4. In some cases, the e.e. could be significantly increased by changing the solvent system.
Sobolev, A., Franssen, M. C. R., Makarova, N., Duburs, G., & de Groot, Æ. (2001). Candida antartica lipase-catalyzed hydrolysis of 4-substituted bis(ethoxycarbonylmethyl) 1,4-dihydropyridine-3,5-dicarboxylates as the key step in the synthesis of optically active dihydropyridines. Tetrahedron: Asymmetry, 11(22), 4559-4569. https://doi.org/10.1016/S0957-4166(00)00441-9