Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

S. Timmers; E. Konings; L. Bilet; R.H. Houtkooper; T. van de Weijer; G.H. Goossens; J. Hoeks; S. van der Krieken; D. Ryu; A.H. Kersten; E. Moonen-Kornips; M.K.C. Hesselink; I. Kunz; V.B. Schrauwen-Hinderling; E.E. Blaak; J. Auwerx; P. Schrauwen

doi:10.1016/j.cmet.2011.10.002

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

S. Timmers, E. Konings, L. Bilet, R.H. Houtkooper, T. van de Weijer, G.H. Goossens, J. Hoeks, S. van der Krieken, D. Ryu, A.H. Kersten, E. Moonen-Kornips, M.K.C. Hesselink, I. Kunz, V.B. Schrauwen-Hinderling, E.E. Blaak, J. Auwerx, P. Schrauwen

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Abstract

Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1 alpha protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.

Original language	English
Pages (from-to)	612-622
Journal	Cell Metabolism
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2011.10.002
Publication status	Published - 2011

Keywords

beta-cell function
life-span
insulin sensitivity
mitochondrial-function
skeletal-muscle
saccharomyces-cerevisiae
sirt1 activation
lipid-metabolism
fat oxidation
exercise

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
Timmers, S. (Creator), Konings, E. (Creator), Bilet, L. (Creator), Houtkooper, R. H. (Creator), van de Weijer, T. (Creator), Hoeks, J. (Creator), van der Krieken, S. (Creator), Ryu, D. (Creator), Kersten, S. (Creator), Moonen-Kornips, E. (Creator), Goossens, G. H. (Creator), Hesselink, M. K. (Creator), Kunz, I. (Creator), Schrauwen-Hinderling, V. B. (Creator), Blaak, E. E. (Creator), Auwerx, J. (Creator) & Schrauwen, P. (Creator), Wageningen University, 8 Nov 2011
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE32357
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Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, A. H., Moonen-Kornips, E., Hesselink, M. K. C., Kunz, I., Schrauwen-Hinderling, V. B., Blaak, E. E., Auwerx, J., & Schrauwen, P. (2011). Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans. Cell Metabolism, 14(5), 612-622. https://doi.org/10.1016/j.cmet.2011.10.002

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title = "Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans",

abstract = "Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1 alpha protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.",

keywords = "beta-cell function, life-span, insulin sensitivity, mitochondrial-function, skeletal-muscle, saccharomyces-cerevisiae, sirt1 activation, lipid-metabolism, fat oxidation, exercise",

author = "S. Timmers and E. Konings and L. Bilet and R.H. Houtkooper and {van de Weijer}, T. and G.H. Goossens and J. Hoeks and {van der Krieken}, S. and D. Ryu and A.H. Kersten and E. Moonen-Kornips and M.K.C. Hesselink and I. Kunz and V.B. Schrauwen-Hinderling and E.E. Blaak and J. Auwerx and P. Schrauwen",

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Timmers, S, Konings, E, Bilet, L, Houtkooper, RH, van de Weijer, T, Goossens, GH, Hoeks, J, van der Krieken, S, Ryu, D, Kersten, AH, Moonen-Kornips, E, Hesselink, MKC, Kunz, I, Schrauwen-Hinderling, VB, Blaak, EE, Auwerx, J & Schrauwen, P 2011, 'Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans', Cell Metabolism, vol. 14, no. 5, pp. 612-622. https://doi.org/10.1016/j.cmet.2011.10.002

TY - JOUR

T1 - Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

AU - Timmers, S.

AU - Konings, E.

AU - Bilet, L.

AU - Houtkooper, R.H.

AU - van de Weijer, T.

AU - Goossens, G.H.

AU - Hoeks, J.

AU - van der Krieken, S.

AU - Ryu, D.

AU - Kersten, A.H.

AU - Moonen-Kornips, E.

AU - Hesselink, M.K.C.

AU - Kunz, I.

AU - Schrauwen-Hinderling, V.B.

AU - Blaak, E.E.

AU - Auwerx, J.

AU - Schrauwen, P.

N1 - WOS:000297142200007

PY - 2011

Y1 - 2011

N2 - Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1 alpha protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.

AB - Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1 alpha protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.

KW - beta-cell function

KW - life-span

KW - insulin sensitivity

KW - mitochondrial-function

KW - skeletal-muscle

KW - saccharomyces-cerevisiae

KW - sirt1 activation

KW - lipid-metabolism

KW - fat oxidation

KW - exercise

U2 - 10.1016/j.cmet.2011.10.002

DO - 10.1016/j.cmet.2011.10.002

M3 - Article

SN - 1550-4131

VL - 14

SP - 612

EP - 622

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

Abstract

Keywords

UN SDGs

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Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans

Cite this