Calorie restriction causes healthy life span extension in the filamentous fungus Podospora anserina

A.D. van Diepeningen, M.F.P.M. Maas, D.H.E.W. Huberts, D.J. Goedbloed, D.J.P. Engelmoer, S.M. Slakhorst, A.B. Koopmanschap, F. Krause, N.A. Dencher, C.H. Sellem, A. Sainsard-Chanet, R.F. Hoekstra, A.J.M. Debets

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)


Although most fungi appear to be immortal, some show systemic senescence within a distinct time frame. Podospora anserina for example shows an irreversible growth arrest within weeks of culturing associated with a destabilization of the mitochondrial genome. Here, we show that calorie restriction (CR), a regimen of under-nutrition without malnutrition, increases not only life span but also forestalls the aging-related decline in fertility. Similar to respiratory chain deficiencies the life span extension is associated with lower levels of intracellular H2O2 measurements and a stabilization of the mitochondrial genome. Unlike respiratory chain deficiencies, CR cultures have a wild-type-like OXPHOS machinery similar to that of well-fed cultures as shown by native electrophoresis of mitochondrial protein complexes. Together, these data indicate that life span extension via CR is fundamentally different from that via respiratory chain mutations: Whereas the latter can be seen as a pathology, the former promotes healthy life span extension and may be an adaptive response
Original languageEnglish
Pages (from-to)60-68
JournalMechanisms of Ageing and Development
Issue number1
Publication statusPublished - 2010


  • respiratory-chain supercomplexes
  • cytochrome-c-oxidase
  • group-ii introns
  • saccharomyces-cerevisiae
  • supramolecular organization
  • mitochondrial-dna
  • senescence
  • dynamics


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