Calcifediol supplementation to reduce pulse pressure in a limited sample of vitamin D deficient older adults with elevated parathyroid hormone levels

Pol Grootswagers, Anouk M.M. Vaes, Michael Tieland, Lisette C.P.G.M. de Groot

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Vitamin D is proposed as an antihypertensive agent, but current evidence is inconclusive. Calcifediol is more potent in raising vitamin D status. It might, therefore, be more effective in lowering pulse pressure than cholecalciferol especially in patients with low vitamin D status and high levels of parathyroid hormone (PTH). This study investigated the efficacy of calcifediol on pulse pressure in older adults with vitamin D deficiency and elevated PTH levels. Supplementation with 15 μg calcifediol resulted in lower pulse pressure (Δ 35.4 mm Hg, 95%CI: 4.8, 66.1 mm Hg, P = 0.021) and PTH levels (Δ 1.83 pmol/l, 95%CI: −0.1, 3.7 pmol/l, P = 0.065) compared to 5 μg calcifediol. These effects were observed in a limited sample size of 16 older adults and therefore need confirmation in a larger trial. In conclusion, supplementation with 15 μg calcifediol might be an effective way to reduce pulse pressure in elderly with vitamin D deficiency and elevated PTH levels.

Original languageEnglish
Pages (from-to)77-82
JournalClinical Nutrition Experimental
Volume24
DOIs
Publication statusPublished - Apr 2019

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Calcifediol
Parathyroid Hormone
Vitamin D
Blood Pressure
Vitamin D Deficiency
Cholecalciferol
Sample Size
Antihypertensive Agents

Keywords

  • Older adults
  • Parathyroid hormone
  • Pulse pressure
  • Randomized clinical trial
  • Vitamin D

Cite this

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title = "Calcifediol supplementation to reduce pulse pressure in a limited sample of vitamin D deficient older adults with elevated parathyroid hormone levels",
abstract = "Vitamin D is proposed as an antihypertensive agent, but current evidence is inconclusive. Calcifediol is more potent in raising vitamin D status. It might, therefore, be more effective in lowering pulse pressure than cholecalciferol especially in patients with low vitamin D status and high levels of parathyroid hormone (PTH). This study investigated the efficacy of calcifediol on pulse pressure in older adults with vitamin D deficiency and elevated PTH levels. Supplementation with 15 μg calcifediol resulted in lower pulse pressure (Δ 35.4 mm Hg, 95{\%}CI: 4.8, 66.1 mm Hg, P = 0.021) and PTH levels (Δ 1.83 pmol/l, 95{\%}CI: −0.1, 3.7 pmol/l, P = 0.065) compared to 5 μg calcifediol. These effects were observed in a limited sample size of 16 older adults and therefore need confirmation in a larger trial. In conclusion, supplementation with 15 μg calcifediol might be an effective way to reduce pulse pressure in elderly with vitamin D deficiency and elevated PTH levels.",
keywords = "Older adults, Parathyroid hormone, Pulse pressure, Randomized clinical trial, Vitamin D",
author = "Pol Grootswagers and Vaes, {Anouk M.M.} and Michael Tieland and {de Groot}, {Lisette C.P.G.M.}",
year = "2019",
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language = "English",
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Calcifediol supplementation to reduce pulse pressure in a limited sample of vitamin D deficient older adults with elevated parathyroid hormone levels. / Grootswagers, Pol; Vaes, Anouk M.M.; Tieland, Michael; de Groot, Lisette C.P.G.M.

In: Clinical Nutrition Experimental, Vol. 24, 04.2019, p. 77-82.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Calcifediol supplementation to reduce pulse pressure in a limited sample of vitamin D deficient older adults with elevated parathyroid hormone levels

AU - Grootswagers, Pol

AU - Vaes, Anouk M.M.

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AU - de Groot, Lisette C.P.G.M.

PY - 2019/4

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AB - Vitamin D is proposed as an antihypertensive agent, but current evidence is inconclusive. Calcifediol is more potent in raising vitamin D status. It might, therefore, be more effective in lowering pulse pressure than cholecalciferol especially in patients with low vitamin D status and high levels of parathyroid hormone (PTH). This study investigated the efficacy of calcifediol on pulse pressure in older adults with vitamin D deficiency and elevated PTH levels. Supplementation with 15 μg calcifediol resulted in lower pulse pressure (Δ 35.4 mm Hg, 95%CI: 4.8, 66.1 mm Hg, P = 0.021) and PTH levels (Δ 1.83 pmol/l, 95%CI: −0.1, 3.7 pmol/l, P = 0.065) compared to 5 μg calcifediol. These effects were observed in a limited sample size of 16 older adults and therefore need confirmation in a larger trial. In conclusion, supplementation with 15 μg calcifediol might be an effective way to reduce pulse pressure in elderly with vitamin D deficiency and elevated PTH levels.

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