Breeding for disease resistance by editing plant susceptibility genes

K. Sun, Z. Zheng, E. Jacobsen, R.G.F. Visser, Y. Bai

Research output: Contribution to journalArticleAcademicpeer-review


Plants are continuously attacked by a broad range of pathogens. World-wide, farmers use large amounts of chemicals to secure crop yield. Breeding for disease resistance is a major objective of breeding activities in order to minimize the yield and quality loss associated with diseases. Although, resistance can often be obtained by introgression of major resistance genes (R-genes) from wild crop relatives, resistance conferred by R-genes is rarely durable. Recently, increased research with a focus on suppression of plant immunity has led to the identification of (potential) disease-susceptibility genes (S-genes) in Arabidopsis. Taking a few examples of conserved S-gene function between Arabidopsis and crops, this review demonstrates how to impair plant S-genes, complementary to the introgression of R-genes, to achieve durable and broad-spectrum resistance.
Original languageEnglish
Article number31
Number of pages5
JournalCAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources
Publication statusPublished - 2014

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