Breed-specific genome-wide association study for purebred and crossbred performance

C.A. Sevillano Del Aguila, S.E.F. Guimaraes, F. Silva, M.P.L. Calus

Research output: Chapter in Book/Report/Conference proceedingConference paper

Abstract

The association of a given SNP with purebred (PB) performance might be different than its association with crossbred (CB) performance, because of interactions of the SNP marker with the environment or the genetic background. Therefore, the aim of the present study is to examine breed-specific associations of SNP to PB and CB performance. For this, we performed a genome-wide association study (GWAS) for back fat thickness (BF) with an approach that implements a genomic best linear unbiased prediction (GBLUP) model considering breed-of-origin of alleles. We observed some same regions for PB and CB performance, but the effects differed when observed in a PB or CB background. As expected, the breed with the lowest genetic correlation for BF between PB and CB, had fewest SNPs in common between PB and CB. Moreover, the effect of a given allele associated to BF in CB depended on the breed it was inherited from. These results suggest that SNP effects depend on the environment and on their genetic background, and are valuable to understand the low responses obtained when selecting PB animals for CB performance. The recognition of important regions associated to performance plus the differentiation of SNP effects according to their breed-of-origin, might inform future prediction models for CB performance.
Original languageEnglish
Title of host publicationProceedings 11th World Congress of Genetics Applied to Livestock Production
Number of pages6
Publication statusPublished - 17 Feb 2018
EventWorld Congress on Genetics Applied to Livestock Production - Auckland, New Zealand
Duration: 11 Feb 201816 Feb 2018

Conference

ConferenceWorld Congress on Genetics Applied to Livestock Production
Abbreviated titleWCGALP 2018
CountryNew Zealand
CityAuckland
Period11/02/1816/02/18

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Sevillano Del Aguila, C. A., Guimaraes, S. E. F., Silva, F., & Calus, M. P. L. (2018). Breed-specific genome-wide association study for purebred and crossbred performance. In Proceedings 11th World Congress of Genetics Applied to Livestock Production [11.332]