Bowel Biofilms: Tipping Points between a Healthy and Compromised Gut?

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Bacterial communities are known to impact human health and disease. Mixed species biofilms, mostly pathogenic in nature, have been observed in dental and gastric infections as well as in intestinal diseases, chronic gut wounds and colon cancer. Apart from the appendix, the presence of thick polymicrobial biofilms in the healthy gut mucosa is still debated. Polymicrobial biofilms containing potential pathogens appear to be an early-warning signal of developing disease and can be regarded as a tipping point between a healthy and a diseased state of the gut mucosa. Key biofilm-forming pathogens and associated molecules hold promise as biomarkers. Criteria to distinguish microcolonies from biofilms are crucial to provide clarity when reporting biofilm-related phenomena in health and disease in the gut.

LanguageEnglish
Pages17-25
JournalTrends in Microbiology
Volume27
Issue number1
Early online date12 Sep 2018
DOIs
Publication statusPublished - Jan 2019

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Biofilms
Mucous Membrane
Intestinal Diseases
Health
Colonic Neoplasms
Stomach
Tooth
Biomarkers
Wounds and Injuries
Infection

Keywords

  • biofilm
  • colorectal cancer
  • microbiota
  • tipping points

Cite this

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title = "Bowel Biofilms: Tipping Points between a Healthy and Compromised Gut?",
abstract = "Bacterial communities are known to impact human health and disease. Mixed species biofilms, mostly pathogenic in nature, have been observed in dental and gastric infections as well as in intestinal diseases, chronic gut wounds and colon cancer. Apart from the appendix, the presence of thick polymicrobial biofilms in the healthy gut mucosa is still debated. Polymicrobial biofilms containing potential pathogens appear to be an early-warning signal of developing disease and can be regarded as a tipping point between a healthy and a diseased state of the gut mucosa. Key biofilm-forming pathogens and associated molecules hold promise as biomarkers. Criteria to distinguish microcolonies from biofilms are crucial to provide clarity when reporting biofilm-related phenomena in health and disease in the gut.",
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Bowel Biofilms: Tipping Points between a Healthy and Compromised Gut? / Tytgat, Hanne L.P.; Nobrega, Franklin L.; van der Oost, John; de Vos, Willem M.

In: Trends in Microbiology, Vol. 27, No. 1, 01.2019, p. 17-25.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Tytgat, Hanne L.P.

AU - Nobrega, Franklin L.

AU - van der Oost, John

AU - de Vos, Willem M.

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AB - Bacterial communities are known to impact human health and disease. Mixed species biofilms, mostly pathogenic in nature, have been observed in dental and gastric infections as well as in intestinal diseases, chronic gut wounds and colon cancer. Apart from the appendix, the presence of thick polymicrobial biofilms in the healthy gut mucosa is still debated. Polymicrobial biofilms containing potential pathogens appear to be an early-warning signal of developing disease and can be regarded as a tipping point between a healthy and a diseased state of the gut mucosa. Key biofilm-forming pathogens and associated molecules hold promise as biomarkers. Criteria to distinguish microcolonies from biofilms are crucial to provide clarity when reporting biofilm-related phenomena in health and disease in the gut.

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KW - colorectal cancer

KW - microbiota

KW - tipping points

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