BOLITA, an Arabidopsis AP2/ERF-like transcription factor that affects cell expansion and proliferation/differentiation pathways

N. Marsch-Martinez, R. Greco, J.D. Becker, S.A. Dixit, J.H.W. Bergervoet, A. Karaba, S. de Folter, A.B. Pereira

Research output: Contribution to journalArticleAcademicpeer-review

57 Citations (Scopus)

Abstract

The BOLITA (BOL) gene, an AP2/ERF transcription factor, was characterized with the help of an activation tag mutant and overexpression lines in Arabidopsis and tobacco. The leaf size of plants overexpressing BOL was smaller than wild type plants due to a reduction in both cell size and cell number. Moreover, severe overexpressors showed ectopic callus formation in roots. Accordingly, global gene expression analysis using the overexpression mutant reflected the alterations in cell proliferation, differentiation and growth through expression changes in RBR, CYCD, and TCP genes, as well as genes involved in cell expansion (i.e. expansins and the actin remodeling factor ADF5). Furthermore, the expression of hormone signaling (i.e. auxin and cytokinin), biosynthesis (i.e. ethylene and jasmonic acid) and regulatory genes was found to be perturbed in bol-D mutant leaves
Original languageEnglish
Pages (from-to)825-843
JournalPlant Molecular Biology
Volume62
Issue number6
DOIs
Publication statusPublished - 2006

Keywords

  • d-type cyclin
  • genome-wide analysis
  • gene-expression
  • dna-binding
  • response regulators
  • microarray analysis
  • negative regulator
  • size control
  • organ size
  • signal-transduction

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