Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials

J.M. Geleijnse, F.J. Kok, D.E. Grobbee

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309 Citations (Scopus)


The objective of the study was to assess the blood pressure response to changes in sodium and potassium intake and examine effect modification by age, gender, blood pressure, body weight and habitual sodium and potassium intake. Randomised trials of sodium reduction or potassium supplementation and blood pressure were identified through reference lists of systematic reviews and an additional MEDLINE search (January 1995-March 2001). A total of 40 sodium trials and 27 potassium trials in adults with a minimum duration of 2 weeks were selected for analysis. Data on changes in electrolyte intake and blood pressure during intervention were collected, as well as data on mean age, gender, body weight, initial electrolyte intake and initial blood pressure of the trial populations. Blood pressure effects of changes in electrolyte intake were assessed by weighted metaregression analysis, overall and in strata of trial population characteristics. Analyses were repeated with adjustment for potential confounders. Sodium reduction (median: -77 mmol/24 h) was associated with a change of -2.54mmHg (95% CI: -3.16, -1.92) in systolic blood pressure and -1.96 mmHg (-2.41, -1.51) in diastolic blood pressure. Corresponding values for increased potassium intake (median: 44 mmol/24 h) were -2.42 mmHg (-3.75, -1.08) and -1.57 mmHg (-2.65, -0.50). Blood pressure response was larger in hypertensives than normotensives, both for sodium (systolic: -5.24 vs -1.26 mmHg, P
Original languageEnglish
Pages (from-to)471-480
JournalJournal of Human Hypertension
Issue number7
Publication statusPublished - 2003


  • placebo-controlled trial
  • converting-enzyme-inhibitor
  • mild essential-hypertension
  • moderate salt restriction
  • reduced dietary-sodium
  • double-blind
  • crossover trial
  • oral potassium
  • nonpharmacologic interventions
  • general-practice


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