Blood pressure decreases more after high-carbohydrate meals than after high-protein meals in overweight adults with elevated blood pressure, but there is no difference after 4 weeks of consuming a carbohydrate-rich or protein-rich diet

K.F.M. Teunissen-Beekman, J. Dopheide, J.M. Geleijnse, S.J. Bakker, E.J. Brink, P.W. de Leeuw, J. Serroyen, M.A. van Baak

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

The replacement of dietary carbohydrates with proteins can lower blood pressure (BP), but the mechanisms remain unclear. This randomized, double-blind, parallel-group study aimed to compare 12-h postprandial sympathetic and hemodynamic responses after high-protein (HP) meals and high-carbohydrate (HC) meals. Fifty-two men and women with untreated elevated BP were tested on d 1 and after 4 wk of supplementation [3 × 20 g protein (HP) or maltodextrin (HC) per day]. No between-group differences were found in postprandial plasma norepinephrine on d 1 and at wk 4. On d 1, postprandial mean arterial pressure (MAP) decreased more in the HC group than in the HP group (P = 0.002). This difference was not present at 4 wk, because the postprandial decline in MAP tended to become larger in the HP group after 4 wk of supplementation (P = 0.07). On both test days, postprandial total peripheral resistance tended to decrease more in the HC group (P <0.08). After 4 wk of supplementation, cardiac output tended to increase more in the HC group (P = 0.08). In conclusion, ingestion of an HP diet induced a smaller decrease in BP on d 1 than did ingestion of an HC diet. This difference disappeared after 4 wk due to a more pronounced decrease in BP in the HP group after 4 wk than on d 1. These findings cannot explain the BP-lowering effect ascribed to dietary proteins.
Original languageEnglish
Pages (from-to)424-429
JournalThe Journal of Nutrition
Volume143
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • systemic hemodynamic-changes
  • randomized-trial
  • sympathetic activity
  • elderly subjects
  • humans
  • insulin
  • activation
  • ingestion
  • hormone
  • glucose

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