Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

William S. Harris; Nathan L. Tintle; Fumiaki Imamura; Frank Qian; Andres V. Ardisson Korat; Matti Marklund; Luc Djoussé; Julie K. Bassett; Pierre Hugues Carmichael; Yun Yu Chen; Yoichiro Hirakawa; Leanne K. Küpers; Federica Laguzzi; Maria Lankinen; Rachel A. Murphy; Cécilia Samieri; Mackenzie K. Senn; Peilin Shi; Jyrki K. Virtanen; Ingeborg A. Brouwer; Kuo Liong Chien; Gudny Eiriksdottir; Nita G. Forouhi; Johanna M. Geleijnse; Graham G. Giles; Vilmundur Gudnason; Catherine Helmer; Allison Hodge; Rebecca Jackson; Kay Tee Khaw; Markku Laakso; Heidi Lai; Danielle Laurin; Karin Leander; Joan Lindsay; Renata Micha; Jaako Mursu; Toshiharu Ninomiya; Wendy Post; Bruce M. Psaty; Ulf Risérus; Jennifer G. Robinson; Aladdin H. Shadyab; Linda Snetselaar; Aleix Sala-Vila; Yangbo Sun; Lyn M. Steffen; Michael Y. Tsai; Nicholas J. Wareham; Alexis C. Wood

doi:10.1038/s41467-021-22370-2

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

William S. Harris^*, Nathan L. Tintle, Fumiaki Imamura, Frank Qian, Andres V. Ardisson Korat, Matti Marklund, Luc Djoussé, Julie K. Bassett, Pierre Hugues Carmichael, Yun Yu Chen, Yoichiro Hirakawa, Leanne K. Küpers, Federica Laguzzi, Maria Lankinen, Rachel A. Murphy, Cécilia Samieri, Mackenzie K. Senn, Peilin Shi, Jyrki K. Virtanen, Ingeborg A. BrouwerKuo Liong Chien, Gudny Eiriksdottir, Nita G. Forouhi, Johanna M. Geleijnse, Graham G. Giles, Vilmundur Gudnason, Catherine Helmer, Allison Hodge, Rebecca Jackson, Kay Tee Khaw, Markku Laakso, Heidi Lai, Danielle Laurin, Karin Leander, Joan Lindsay, Renata Micha, Jaako Mursu, Toshiharu Ninomiya, Wendy Post, Bruce M. Psaty, Ulf Risérus, Jennifer G. Robinson, Aladdin H. Shadyab, Linda Snetselaar, Aleix Sala-Vila, Yangbo Sun, Lyn M. Steffen, Michael Y. Tsai, Nicholas J. Wareham, Alexis C. Wood

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

153 Citations (Scopus)

Abstract

The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

Original language	English
Pages (from-to)	2329
Number of pages	1
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-22370-2
Publication status	Published - 22 Apr 2021

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Harris, W. S., Tintle, N. L., Imamura, F., Qian, F., Ardisson Korat, A. V., Marklund, M., Djoussé, L., Bassett, J. K., Carmichael, P. H., Chen, Y. Y., Hirakawa, Y., Küpers, L. K., Laguzzi, F., Lankinen, M., Murphy, R. A., Samieri, C., Senn, M. K., Shi, P., Virtanen, J. K., ... Wood, A. C. (2021). Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Nature Communications, 12(1), 2329. https://doi.org/10.1038/s41467-021-22370-2

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title = "Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies",

abstract = "The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.",

author = "Harris, {William S.} and Tintle, {Nathan L.} and Fumiaki Imamura and Frank Qian and {Ardisson Korat}, {Andres V.} and Matti Marklund and Luc Djouss{\'e} and Bassett, {Julie K.} and Carmichael, {Pierre Hugues} and Chen, {Yun Yu} and Yoichiro Hirakawa and K{\"u}pers, {Leanne K.} and Federica Laguzzi and Maria Lankinen and Murphy, {Rachel A.} and C{\'e}cilia Samieri and Senn, {Mackenzie K.} and Peilin Shi and Virtanen, {Jyrki K.} and Brouwer, {Ingeborg A.} and Chien, {Kuo Liong} and Gudny Eiriksdottir and Forouhi, {Nita G.} and Geleijnse, {Johanna M.} and Giles, {Graham G.} and Vilmundur Gudnason and Catherine Helmer and Allison Hodge and Rebecca Jackson and Khaw, {Kay Tee} and Markku Laakso and Heidi Lai and Danielle Laurin and Karin Leander and Joan Lindsay and Renata Micha and Jaako Mursu and Toshiharu Ninomiya and Wendy Post and Psaty, {Bruce M.} and Ulf Ris{\'e}rus and Robinson, {Jennifer G.} and Shadyab, {Aladdin H.} and Linda Snetselaar and Aleix Sala-Vila and Yangbo Sun and Steffen, {Lyn M.} and Tsai, {Michael Y.} and Wareham, {Nicholas J.} and Wood, {Alexis C.}",

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doi = "10.1038/s41467-021-22370-2",

language = "English",

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Harris, WS, Tintle, NL, Imamura, F, Qian, F, Ardisson Korat, AV, Marklund, M, Djoussé, L, Bassett, JK, Carmichael, PH, Chen, YY, Hirakawa, Y, Küpers, LK, Laguzzi, F, Lankinen, M, Murphy, RA, Samieri, C, Senn, MK, Shi, P, Virtanen, JK, Brouwer, IA, Chien, KL, Eiriksdottir, G, Forouhi, NG, Geleijnse, JM, Giles, GG, Gudnason, V, Helmer, C, Hodge, A, Jackson, R, Khaw, KT, Laakso, M, Lai, H, Laurin, D, Leander, K, Lindsay, J, Micha, R, Mursu, J, Ninomiya, T, Post, W, Psaty, BM, Risérus, U, Robinson, JG, Shadyab, AH, Snetselaar, L, Sala-Vila, A, Sun, Y, Steffen, LM, Tsai, MY, Wareham, NJ & Wood, AC 2021, 'Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies', Nature Communications, vol. 12, no. 1, pp. 2329. https://doi.org/10.1038/s41467-021-22370-2

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T1 - Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

AU - Harris, William S.

AU - Tintle, Nathan L.

AU - Imamura, Fumiaki

AU - Qian, Frank

AU - Ardisson Korat, Andres V.

AU - Marklund, Matti

AU - Djoussé, Luc

AU - Bassett, Julie K.

AU - Carmichael, Pierre Hugues

AU - Chen, Yun Yu

AU - Hirakawa, Yoichiro

AU - Küpers, Leanne K.

AU - Laguzzi, Federica

AU - Lankinen, Maria

AU - Murphy, Rachel A.

AU - Samieri, Cécilia

AU - Senn, Mackenzie K.

AU - Shi, Peilin

AU - Virtanen, Jyrki K.

AU - Brouwer, Ingeborg A.

AU - Chien, Kuo Liong

AU - Eiriksdottir, Gudny

AU - Forouhi, Nita G.

AU - Geleijnse, Johanna M.

AU - Giles, Graham G.

AU - Gudnason, Vilmundur

AU - Helmer, Catherine

AU - Hodge, Allison

AU - Jackson, Rebecca

AU - Khaw, Kay Tee

AU - Laakso, Markku

AU - Lai, Heidi

AU - Laurin, Danielle

AU - Leander, Karin

AU - Lindsay, Joan

AU - Micha, Renata

AU - Mursu, Jaako

AU - Ninomiya, Toshiharu

AU - Post, Wendy

AU - Psaty, Bruce M.

AU - Risérus, Ulf

AU - Robinson, Jennifer G.

AU - Shadyab, Aladdin H.

AU - Snetselaar, Linda

AU - Sala-Vila, Aleix

AU - Sun, Yangbo

AU - Steffen, Lyn M.

AU - Tsai, Michael Y.

AU - Wareham, Nicholas J.

AU - Wood, Alexis C.

PY - 2021/4/22

Y1 - 2021/4/22

N2 - The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

AB - The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

U2 - 10.1038/s41467-021-22370-2

DO - 10.1038/s41467-021-22370-2

M3 - Article

C2 - 33888689

AN - SCOPUS:85105757201

SN - 2041-1723

VL - 12

SP - 2329

JO - Nature Communications

JF - Nature Communications

IS - 1

ER -

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

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