Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans

H. van der Woude; A. Gliszczynska-Swiglo; K. Struijs; A. Smeets; G.M. Alink; I.M.C.M. Rietjens

doi:10.1016/S0304-3835(03)00412-9

Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans

H. van der Woude, A. Gliszczynska-Swiglo, K. Struijs, A. Smeets, G.M. Alink, I.M.C.M. Rietjens

Research output: Contribution to journal › Article › Academic › peer-review

157 Citations (Scopus)

Abstract

Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	41-47
Journal	Cancer Letters
Volume	200
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(03)00412-9
Publication status	Published - 2003

Keywords

estrogen-binding-sites
breast-cancer cells
in-vitro
phosphatidylinositol 3-kinase
dietary flavonoids
growth
genistein
inhibition
metabolism
phytoestrogens

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0304-3835(03)00412-9

Cite this

@article{97eb8812b2ec4c0482c73b165595f05d,

title = "Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans",

abstract = "Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect. (C) 2003 Elsevier Ireland Ltd. All rights reserved.",

keywords = "estrogen-binding-sites, breast-cancer cells, in-vitro, phosphatidylinositol 3-kinase, dietary flavonoids, growth, genistein, inhibition, metabolism, phytoestrogens",

author = "{van der Woude}, H. and A. Gliszczynska-Swiglo and K. Struijs and A. Smeets and G.M. Alink and I.M.C.M. Rietjens",

year = "2003",

doi = "10.1016/S0304-3835(03)00412-9",

language = "English",

volume = "200",

pages = "41--47",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans

AU - van der Woude, H.

AU - Gliszczynska-Swiglo, A.

AU - Struijs, K.

AU - Smeets, A.

AU - Alink, G.M.

AU - Rietjens, I.M.C.M.

PY - 2003

Y1 - 2003

N2 - Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

AB - Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

KW - estrogen-binding-sites

KW - breast-cancer cells

KW - in-vitro

KW - phosphatidylinositol 3-kinase

KW - dietary flavonoids

KW - growth

KW - genistein

KW - inhibition

KW - metabolism

KW - phytoestrogens

U2 - 10.1016/S0304-3835(03)00412-9

DO - 10.1016/S0304-3835(03)00412-9

M3 - Article

SN - 0304-3835

VL - 200

SP - 41

EP - 47

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this