Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans

H. van der Woude, A. Gliszczynska-Swiglo, K. Struijs, A. Smeets, G.M. Alink, I.M.C.M. Rietjens

Research output: Contribution to journalArticleAcademicpeer-review

128 Citations (Scopus)

Abstract

Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)41-47
JournalCancer Letters
Volume200
Issue number1
DOIs
Publication statusPublished - 2003

Keywords

  • estrogen-binding-sites
  • breast-cancer cells
  • in-vitro
  • phosphatidylinositol 3-kinase
  • dietary flavonoids
  • growth
  • genistein
  • inhibition
  • metabolism
  • phytoestrogens

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