Biotransformation of limonene by bacteria, fungi, yeasts, and plants

W.A. Duetz, H.J. Bouwmeester, J.B. Beilen, B. Witholt

    Research output: Contribution to journalArticleAcademicpeer-review

    163 Citations (Scopus)

    Abstract

    The past 5 years have seen significant progress in the field of limonene biotransformation, especially with regard to the regiospecificity of microbial biocatalysts. Whereas earlier only regiospecific biocatalysts for the 1,2 position (limonene-1,2-diol) and the 8-position (¿±-terpineol) were available, recent reports describe microbial biocatalysts specifically hydroxylating the 3-position (isopiperitenol), 6-position (carveol and carvone), and 7-position (perillyl alcohol, perillylaaldehyde, and perillic acid). The present review also includes the considerable progress made in the characterization of plant P-450 limonene hydroxylases and the cloning of the encoding genes.
    Original languageEnglish
    Pages (from-to)269-277
    JournalApplied Microbiology and Biotechnology
    Volume61
    DOIs
    Publication statusPublished - 2003

    Fingerprint

    Biotransformation
    Fungi
    Yeasts
    perilla alcohol
    Bacteria
    Enzymes
    Organism Cloning
    Genes
    limonene

    Keywords

    • microbiological transformations
    • bacillus-stearothermophilus
    • pseudomonas-putida
    • soil pseudomonad
    • functional expression
    • degradation pathway
    • escherichia-coli
    • selenium dioxide
    • perillic acid
    • bioconversion

    Cite this

    Duetz, W.A. ; Bouwmeester, H.J. ; Beilen, J.B. ; Witholt, B. / Biotransformation of limonene by bacteria, fungi, yeasts, and plants. In: Applied Microbiology and Biotechnology. 2003 ; Vol. 61. pp. 269-277.
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    abstract = "The past 5 years have seen significant progress in the field of limonene biotransformation, especially with regard to the regiospecificity of microbial biocatalysts. Whereas earlier only regiospecific biocatalysts for the 1,2 position (limonene-1,2-diol) and the 8-position (¿±-terpineol) were available, recent reports describe microbial biocatalysts specifically hydroxylating the 3-position (isopiperitenol), 6-position (carveol and carvone), and 7-position (perillyl alcohol, perillylaaldehyde, and perillic acid). The present review also includes the considerable progress made in the characterization of plant P-450 limonene hydroxylases and the cloning of the encoding genes.",
    keywords = "microbiological transformations, bacillus-stearothermophilus, pseudomonas-putida, soil pseudomonad, functional expression, degradation pathway, escherichia-coli, selenium dioxide, perillic acid, bioconversion",
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    Biotransformation of limonene by bacteria, fungi, yeasts, and plants. / Duetz, W.A.; Bouwmeester, H.J.; Beilen, J.B.; Witholt, B.

    In: Applied Microbiology and Biotechnology, Vol. 61, 2003, p. 269-277.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Biotransformation of limonene by bacteria, fungi, yeasts, and plants

    AU - Duetz, W.A.

    AU - Bouwmeester, H.J.

    AU - Beilen, J.B.

    AU - Witholt, B.

    PY - 2003

    Y1 - 2003

    N2 - The past 5 years have seen significant progress in the field of limonene biotransformation, especially with regard to the regiospecificity of microbial biocatalysts. Whereas earlier only regiospecific biocatalysts for the 1,2 position (limonene-1,2-diol) and the 8-position (¿±-terpineol) were available, recent reports describe microbial biocatalysts specifically hydroxylating the 3-position (isopiperitenol), 6-position (carveol and carvone), and 7-position (perillyl alcohol, perillylaaldehyde, and perillic acid). The present review also includes the considerable progress made in the characterization of plant P-450 limonene hydroxylases and the cloning of the encoding genes.

    AB - The past 5 years have seen significant progress in the field of limonene biotransformation, especially with regard to the regiospecificity of microbial biocatalysts. Whereas earlier only regiospecific biocatalysts for the 1,2 position (limonene-1,2-diol) and the 8-position (¿±-terpineol) were available, recent reports describe microbial biocatalysts specifically hydroxylating the 3-position (isopiperitenol), 6-position (carveol and carvone), and 7-position (perillyl alcohol, perillylaaldehyde, and perillic acid). The present review also includes the considerable progress made in the characterization of plant P-450 limonene hydroxylases and the cloning of the encoding genes.

    KW - microbiological transformations

    KW - bacillus-stearothermophilus

    KW - pseudomonas-putida

    KW - soil pseudomonad

    KW - functional expression

    KW - degradation pathway

    KW - escherichia-coli

    KW - selenium dioxide

    KW - perillic acid

    KW - bioconversion

    U2 - 10.1007/s00253-003-1221-y

    DO - 10.1007/s00253-003-1221-y

    M3 - Article

    VL - 61

    SP - 269

    EP - 277

    JO - Applied Microbiology and Biotechnology

    JF - Applied Microbiology and Biotechnology

    SN - 0175-7598

    ER -