Biosynthesis, regulation, and domestication of bitterness in cucumber

Y. Shang, Y. Ma, H.J. Bouwmeester

Research output: Contribution to journalArticleAcademicpeer-review

187 Citations (Scopus)

Abstract

Cucurbitacins are triterpenoids that confer a bitter taste in cucurbits such as cucumber, melon, watermelon, squash, and pumpkin. These compounds discourage most pests on the plant and have also been shown to have antitumor properties. With genomics and biochemistry, we identified nine cucumber genes in the pathway for biosynthesis of cucurbitacin C and elucidated four catalytic steps.We discovered transcription factors Bl (Bitter leaf) and Bt (Bitter fruit) that regulate this pathway in leaves and fruits, respectively. Traces in genomic signatures indicated that selection imposed on Bt during domestication led to derivation of nonbitter cucurbits from their bitter ancestors.
Original languageEnglish
Pages (from-to)1084-1088
JournalScience
Volume346
Issue number6213
DOIs
Publication statusPublished - 2014

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