Biosensor comprising a modified metal surface and method for the modification of a metal surface

J.M. Alonso Carnicero (Inventor), M.C.R. Franssen (Inventor), A.A.M. Bielen (Inventor), L.M.W. Scheres (Inventor), A.K. Schütz-Trilling (Inventor), W.B. Zeper (Inventor), J.T. Zuilhof (Inventor), P.A.M. van Paassen (Inventor), W. Olthuis (Inventor), L. Rassaei (Inventor)

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Abstract

The present invention relates to a device for the detection of an analyte in a fluid, the device comprising: (a) a working electrode comprising a modified metal surface, wherein: (1) the metal is selected from the group consisting of Ru, Rh, Pd, Ag, Ir, Pt and Au; (2) an enzyme is covalently attached to the metal surface via an alkyloxy or an alkenyloxy moiety and, optionally, a linker moiety; (3)the alkyloxy or alkenyloxy moiety is covalently bonded to said metal surface via the alkyloxy or alkenyloxy O- atom; and (4) the linker moiety, if present, is covalently bonded to theenzyme and to the alkyloxy or alkenyloxy moiety; (b) a reference electrode; and (c) means for detecting an electricalsignal, the means being operationally coupled to at least working electrode (a) and reference electrode (b). The device according to the invention is also referred to as a biosensor. The invention also relates to a process for the modification of a metal surface and to a modified metal surface obtainable by the process. Furthermore, the invention relates to an electrode comprising said modified metal surface, and to a biosensor comprising said modified metal surface.
Original languageEnglish
Patent numberWO2016018148
Priority date30/07/14
Publication statusPublished - 4 Feb 2016

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Alonso Carnicero, J. M., Franssen, M. C. R., Bielen, A. A. M., Scheres, L. M. W., Schütz-Trilling, A. K., Zeper, W. B., ... Rassaei, L. (2016). Biosensor comprising a modified metal surface and method for the modification of a metal surface. (Patent No. WO2016018148).