Biomimetic mineralization of calcium phosphate on a functionalizaed porous silicon carbide biomaterial

A. Dey, C.J. van de Hoogen, M. Rosso, N.J.H.G.M. Lousberg, M.M.R.M. Hendrix, H. Friedrich, J. Ramirez Rico, H. Zuilhof, G. de With, N.A.J.M. Sommerdijk

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Porous biomorphic silicon carbide (bioSiC) is a structurally realistic, high-strength, and biocompatible material which is promising for application in load-bearing implants. The deposition of an osteoconductive coating is essential for further improvement of its integration with the surrounding tissue. A new strategy towards biomimetic calcium phosphate coatings on bioSiC is described. X-ray photoelectron spectroscopy (XPS) analysis shows that using 10-undecenoic acid methyl ester a covalently bound monolayer can be synthesized on the surface of the bioSiC. After hydrolysis it exposes carboxylic acid groups that promote the selective nucleation and growth of a very well-defined crystalline layer of calcium phosphate. The resulting calcium phosphate coating is characterized by X-ray diffraction and electron microscopy techniques. Further, ion beam imaging is employed to quantify the mineral deposition meanwhile, three-dimensional dual-beam imaging (FIB/SEM) is used to visualize the bioSiC/mineral interface. The monolayer is show to actively induce the nucleation of a well-defined and highly crystalline mixed octacalcium phosphate/hydroxyapatite (OCP/HAP) coating on implantable bioSiC substrates with complex geometry. The mild biomimetic procedure, in principle, allows for the inclusion of bioactive compounds that aid in tissue regeneration. Moreover, the mixed OCP/HAP phase will have a higher solubility compared to HAP, which, in combination with its porous structure, is expected to render the coating more reabsorbable than standard HAP coatings.
Original languageEnglish
Pages (from-to)694-699
JournalChemPlusChem
Volume77
Issue number8
DOIs
Publication statusPublished - 2012

Keywords

  • octacalcium phosphate
  • biomedical applications
  • bioactive glass
  • in-vitro
  • hydroxyapatite
  • bone
  • transformation
  • ceramics
  • crystallization
  • interfaces

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