Biomass growth and kLa estimation using online and offline measurements

Z.I.T.A. Soons, J. Shi, L.A. van der Pol, G. van Straten, A.J.B. van Boxtel

Research output: Contribution to conferenceConference paperAcademicpeer-review

2 Citations (Scopus)

Abstract

Measurement of the key process variables is essential during biopharmaceutical production. These measurements are often not available online. This work combines frequent online measurements with infrequent offline measurements to estimate the specific growth rate, biomass, and the oxygen mass transfer coefficient during continuous and fed-batch cultivations of Bordetella pertussis online using an Extended Kalman filter, parameter adaptation, and learning.
Original languageEnglish
Publication statusPublished - 2007
Event10th Computer Application in Biotechnology, Symposium -
Duration: 4 Jun 20076 Jun 2007

Conference

Conference10th Computer Application in Biotechnology, Symposium
Period4/06/076/06/07

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    Soons, Z. I. T. A., Shi, J., van der Pol, L. A., van Straten, G., & van Boxtel, A. J. B. (2007). Biomass growth and kLa estimation using online and offline measurements. Paper presented at 10th Computer Application in Biotechnology, Symposium, . https://edepot.wur.nl/39255