Bioconjugation of Different Nanosurfaces With Biorecognition Molecules for the Development of Selective Nanosensor Platforms

Satish K. Tuteja, Ruchi Mutreja, Suresh Neethirajan, Sven Ingebrandt

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

With the rising need in the field of point-of-care and on-field diagnostics, various bioreceptor-functionalized nanostructures have been explored for the realization of highly sensitive nano(bio)sensors. Some desirable features of a biosensor include the capability of detection sensitivity in the range of interest, simple sample preprocessing, reproducibility, real-time monitoring of target analytes, and possible regeneration. Antibodies and aptamers (single-stranded DNA or RNA) are the most versatilely used bioreceptors that have been extensively studied and applied successfully for the biosensor development, apart from enzymes, whole cells, and organelles. The response characteristics of nanosensor also depend on the type of nanomaterials embedded on the sensor and the chemistry used for tagging the nanomaterial with the biorecognition element. In this chapter, information has been provided on the functionalization of nanosensor surfaces with biorecognition elements via different conjugation chemistries.
Original languageEnglish
Title of host publicationAdvances in Nanosensors for Biological and Environmental Analysis
EditorsAkash Deep, Sandeep Kumar
PublisherElsevier
Chapter5
Pages79-94
ISBN (Print)9780128174562
DOIs
Publication statusPublished - 2019
Externally publishedYes

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