Bioassay-derived dioxin equivalent concentrations in gonads and livers of the Atlantic cod females from the Baltic Sea

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Abstract

The DR-H4IIE.Luc bioassay is based on the ability of dioxin and dioxin-like contaminants to activate the AhR and its signal transduction pathway, a mechanism through which these contaminants elicit their toxic effects. The bioassay was used to examine the total dioxin-equivalent (TEQ) toxicity in gonads and livers of cod females from the southern Baltic Sea. The bioassay-derived TEQ-luc was measured after 24-h and 48-h exposure periods. Mean concentrations in the 24-h bioassay were 95 and 35 pg TEQ-luc g-1 lipid in gonads and livers, respectively, and 58 and 38 pg TEQ-luc g-1 lipid in the 48-h bioassay, respectively. The 48-h TEQ-luc levels displayed significant relationships with SPCB7 and selected PCB congeners but not with the TEQDLPCB-REP. Levels in gonads approached 10% of the LC50 for developing larvae of other marine fish, yet the impact on survival of the cod during its early life remains to be assessed in a future
Original languageEnglish
Pages (from-to)1829-1834
JournalEcotoxicology and Environmental Safety
Volume73
Issue number8
DOIs
Publication statusPublished - 2010

Keywords

  • dibenzo-p-dioxins
  • in-vitro bioassay
  • calux bioassay
  • aromatic-hydrocarbons
  • dr-calux(r) bioassay
  • expression calux
  • active compounds
  • fish
  • sediments
  • biphenyls

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