Bioactivity-based screening of antobiotics and hormones

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    53 Citations (Scopus)

    Abstract

    Bioactivity-based screening methods are relatively cheap, quick and easy to use tools. Especially with respect to antimicrobial residues and compounds with hormonal activity, they form a very cost-effective alternative to physical chemical methods in large-scale surveillance and monitoring programs, where their main purpose is to identify samples that require additional chemical confirmation. A major advantage is their intrinsic capability to detect unknown compounds and new hazards. This review shows an overview of the available methods and their potential and limitations for regulatory control.
    Original languageEnglish
    Pages (from-to)8035-8050
    JournalJournal of Chromatography. A, Including electrophoresis and other separation methods
    Volume1216
    Issue number46
    DOIs
    Publication statusPublished - 2009

    Keywords

    • reporter gene assay
    • green fluorescent protein
    • beta-lactam antibiotics
    • yeast estrogen bioassay
    • in-vitro assays
    • human progesterone-receptor
    • tandem mass-spectrometry
    • cancer cell-line
    • androgen receptor
    • breast-cancer

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