Projects per year
Abstract
Hierarchical bioactive surfaces are created by visible-light-induced surface-initiated living radical polymerization employing tris[2-phenylpyridinato-C2,N]iridium(III) as a photocatalyst. The hierarchical antifouling diblock copolymer structures consist of N-(2-hydroxypropyl)-methacrylamide (first block) and carboxybetaine methacrylate (second block). The living nature of the polymerization is shown by a linear increase in layer thickness (as measured by atomic force microscopy) and reinitiation of the polymerization to create a patterned second block of polymer. The chemical structure of the brushes is confirmed by X-ray photoelectron spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy measurements. The block copolymer brushes demonstrate excellent antifouling properties when exposed to single-protein solutions or to bovine serum. The second carboxybetaine block of the hierarchical antifouling structures can effectively be biofunctionalized with an anti-fibrinogen antibody. The coated surfaces show a high affinity and specificity to fibrinogen, while preventing nonspecific adsorption from other proteins in bovine serum.
Original language | English |
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Article number | 1900351 |
Journal | Advanced Materials Interfaces |
Volume | 6 |
Issue number | 12 |
Early online date | 2 May 2019 |
DOIs | |
Publication status | Published - 21 Jun 2019 |
Keywords
- biosensing
- controlled living polymerization
- nonfouling coatings
- zwitterionic polymer brushes
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Dive into the research topics of 'Bioactive Antifouling Surfaces by Visible-Light-Triggered Polymerization'. Together they form a unique fingerprint.Projects
- 2 Finished
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FoodSmartphone: Smartphone analyzers for on-site testing of food quality and safety
1/01/17 → 31/03/21
Project: EU research project
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MC ITN network FOODSMARTPHONE (KB-37-002-016, KB-23-002-031)
Gerssen, A. (Project Leader)
1/01/17 → 31/12/22
Project: LVVN project