Abstract
Hierarchical bioactive surfaces are created by visible-light-induced surface-initiated living radical polymerization employing tris[2-phenylpyridinato-C2,N]iridium(III) as a photocatalyst. The hierarchical antifouling diblock copolymer structures consist of N-(2-hydroxypropyl)-methacrylamide (first block) and carboxybetaine methacrylate (second block). The living nature of the polymerization is shown by a linear increase in layer thickness (as measured by atomic force microscopy) and reinitiation of the polymerization to create a patterned second block of polymer. The chemical structure of the brushes is confirmed by X-ray photoelectron spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy measurements. The block copolymer brushes demonstrate excellent antifouling properties when exposed to single-protein solutions or to bovine serum. The second carboxybetaine block of the hierarchical antifouling structures can effectively be biofunctionalized with an anti-fibrinogen antibody. The coated surfaces show a high affinity and specificity to fibrinogen, while preventing nonspecific adsorption from other proteins in bovine serum.
| Original language | English |
|---|---|
| Article number | 1900351 |
| Journal | Advanced Materials Interfaces |
| Volume | 6 |
| Issue number | 12 |
| Early online date | 2 May 2019 |
| DOIs | |
| Publication status | Published - 21 Jun 2019 |
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Keywords
- biosensing
- controlled living polymerization
- nonfouling coatings
- zwitterionic polymer brushes
Cite this
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Bioactive Antifouling Surfaces by Visible-Light-Triggered Polymerization. / Kuzmyn, Andriy R.; Nguyen, Ai T.; Zuilhof, Han; Baggerman, Jacob.
In: Advanced Materials Interfaces, Vol. 6, No. 12, 1900351, 21.06.2019.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Bioactive Antifouling Surfaces by Visible-Light-Triggered Polymerization
AU - Kuzmyn, Andriy R.
AU - Nguyen, Ai T.
AU - Zuilhof, Han
AU - Baggerman, Jacob
PY - 2019/6/21
Y1 - 2019/6/21
N2 - Hierarchical bioactive surfaces are created by visible-light-induced surface-initiated living radical polymerization employing tris[2-phenylpyridinato-C2,N]iridium(III) as a photocatalyst. The hierarchical antifouling diblock copolymer structures consist of N-(2-hydroxypropyl)-methacrylamide (first block) and carboxybetaine methacrylate (second block). The living nature of the polymerization is shown by a linear increase in layer thickness (as measured by atomic force microscopy) and reinitiation of the polymerization to create a patterned second block of polymer. The chemical structure of the brushes is confirmed by X-ray photoelectron spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy measurements. The block copolymer brushes demonstrate excellent antifouling properties when exposed to single-protein solutions or to bovine serum. The second carboxybetaine block of the hierarchical antifouling structures can effectively be biofunctionalized with an anti-fibrinogen antibody. The coated surfaces show a high affinity and specificity to fibrinogen, while preventing nonspecific adsorption from other proteins in bovine serum.
AB - Hierarchical bioactive surfaces are created by visible-light-induced surface-initiated living radical polymerization employing tris[2-phenylpyridinato-C2,N]iridium(III) as a photocatalyst. The hierarchical antifouling diblock copolymer structures consist of N-(2-hydroxypropyl)-methacrylamide (first block) and carboxybetaine methacrylate (second block). The living nature of the polymerization is shown by a linear increase in layer thickness (as measured by atomic force microscopy) and reinitiation of the polymerization to create a patterned second block of polymer. The chemical structure of the brushes is confirmed by X-ray photoelectron spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy measurements. The block copolymer brushes demonstrate excellent antifouling properties when exposed to single-protein solutions or to bovine serum. The second carboxybetaine block of the hierarchical antifouling structures can effectively be biofunctionalized with an anti-fibrinogen antibody. The coated surfaces show a high affinity and specificity to fibrinogen, while preventing nonspecific adsorption from other proteins in bovine serum.
KW - biosensing
KW - controlled living polymerization
KW - nonfouling coatings
KW - zwitterionic polymer brushes
U2 - 10.1002/admi.201900351
DO - 10.1002/admi.201900351
M3 - Article
VL - 6
JO - Advanced Material Interfaces
JF - Advanced Material Interfaces
SN - 2196-7350
IS - 12
M1 - 1900351
ER -