beta-Lactam and glycopeptide antibiotics: first and last line of defense?

S. Jovetic, Yang Yang Zhu, G.L. Marcone, F. Marinelli, J. Tramper

Research output: Contribution to journalArticleAcademicpeer-review

57 Citations (Scopus)

Abstract

Most infections are caused by bacteria, many of which are ever-evolving and resistant to nearly all available antibiotics beta-Lactams and glycopeptides are used to combat these infections by inhibiting bacterial cell-wall synthesis This mechanism remains an interesting target in the search for new antibiotics in light of failed genomic approaches and the limited input of major pharmaceutical companies Several strategies have enriched the pipeline of bacterial cell-wall inhibitors examples include combining screening strategies with lesser explored microbial diversity, or reinventing known scaffolds based on structure-function relationships Drugs developed using novel strategies will contribute to the arsenal in fight against the continued emergence of bacterial resistance
Original languageEnglish
Pages (from-to)596-604
JournalTrends in Biotechnology
Volume28
Issue number12
DOIs
Publication statusPublished - 2010

Keywords

  • resistant staphylococcus-aureus
  • methicillin resistance
  • antimicrobial resistance
  • lipid-ii
  • streptococcus-pneumoniae
  • vancomycin resistance
  • crystal-structures
  • biological cost
  • united-states
  • fitness cost

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