Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of natural Killer cell activity and early inflammatory response (Randomized, double-blinded, placebo-controlled trial)

J.H. Kwak, S.H. Baek, Y. Woo, J.K. Han, L. van Lee

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Abstract

Background - In vitro and animal studies have demonstrated that Chlorella is a potent biological response modifier on immunity. However, there were no direct evidences for the effect of Chlorella supplementation on immune/inflammation response in healthy humans. Methods - This study was designed for an 8-week randomized, double-blinded, placebo-controlled trial: 5g of Chlorella (n=23) or Placebo (n=28) as form of tablets. Mainly, cytotoxic activities of Natural killer (NK) cells and serum concentrations of interferon-¿, interleukin-1ß and interleukin-12 were measured. Results - After the 8-week, serum concentrations of interferon-¿ (p
Original languageEnglish
Article number53
JournalNutrition Journal
Volume11
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • hot-water extract
  • accelerates dioxin excretion
  • blood mononuclear-cells
  • unicellular green-algae
  • listeria-monocytogenes
  • ifn-gamma
  • interferon-gamma
  • macrophage activation
  • independent mechanism
  • escherichia-coli

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