Bacterial Histidine Kinases as Novel Antibacterial Drug Targets

A.E. Bem, N.R. Velikova, M.T. Pellicer, P. van Baarlen, A. Marina, J.M. Wells

Research output: Contribution to journalArticleAcademicpeer-review

100 Citations (Scopus)

Abstract

Bacterial histidine kinases (HKs) are promising targets for novel antibacterials. Bacterial HKs are part of bacterial two-component systems (TCSs), the main signal transduction pathways in bacteria, regulating various processes including virulence, secretion systems and antibiotic resistance. In this review, we discuss the biological importance of TCSs and bacterial HKs for the discovery of novel antibacterials, as well as published TCS and HK inhibitors that can be used as a starting point for structure-based approaches to develop novel antibacterials.
Original languageEnglish
Pages (from-to)213-224
JournalAcs Chemical Biology
Volume10
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • 2-component signal-transduction
  • structure-based discovery
  • staphylococcus-aureus
  • mycobacterium-tuberculosis
  • escherichia-coli
  • multidrug-resistance
  • response regulator
  • vancomycin resistance
  • antibiotic-resistance
  • streptococcus-mutans

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