Auxin enters the matrix - assembly of response machineries for specific outputs

A.S. Lokerse, D. Weijers

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)


The basic mechanism of auxin as a modulator of gene expression is now well understood. Interactions among three components are required for this process. Auxin is first perceived by its receptor, which then promotes degradation of inhibitors of auxin response transcription factors. These in turn are released from inhibition and modify expression of target genes. How this simple signaling pathway is able to regulate a diverse range of auxin responses is not as well understood, however a clue lies in the existence of large gene families for all components. Recent data indicates that diversification of gene expression patterns, protein activity, and protein-protein interactions among components establishes a matrix of response machineries that generates specific outputs from the generic auxin signal
Original languageEnglish
Pages (from-to)520-526
JournalCurrent Opinion in Plant Biology
Issue number5
Publication statusPublished - 2009


  • lateral root-formation
  • arf gene families
  • box protein tir1
  • transcriptional repression
  • arabidopsis embryogenesis
  • aux/iaa proteins
  • monopteros
  • receptor
  • embryo
  • overexpression


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