To ensure consistency between fed-batch cultivations for the production of vaccines or other bio-pharmaceuticals it is desirable to control the specific growth rate to a pre-set constant value. This is a challenge because the dynamics of the process is considerably changing due to the increase in volume and biomass as cultivation proceeds. Standard adaptive control can overcome this, but requires online identification by perturbing the system. In this study, an adaptive controller is designed, that does not demand online identification. The coarse adjustment of the controller gains is based on mass balances, while the fine tuning is performed by a novel tuning device that exploits the dynamics of the estimated error in specific growth rate. The only required measurement is the oxygen uptake rate. The controller and automatic tuning device are verified in simulation, and put to a test in laboratory experiments with Bordetella pertussis.
|Publication status||Published - 2006|
|Event||Chemical Process Control 7 - |
Duration: 9 Jan 2006 → 13 Jan 2006
|Conference||Chemical Process Control 7|
|Period||9/01/06 → 13/01/06|