Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

Yasumoto Oyadomari; Yasuyuki Goto; Keisuke Suganuma; Shin Ichiro Kawazu; Leontine E. Becking; Nobuhiro Fusetani; Yoichi Nakao

doi:10.3390/md22040171

Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

Yasumoto Oyadomari, Yasuyuki Goto, Keisuke Suganuma, Shin Ichiro Kawazu, Leontine E. Becking, Nobuhiro Fusetani, Yoichi Nakao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC₅₀ value of 0.74 µM.

Original language	English
Article number	171
Journal	Marine Drugs
Volume	22
Issue number	4
DOIs	https://doi.org/10.3390/md22040171
Publication status	Published - Apr 2024

Keywords

anti-leishmanial activity
aurantosides
marine natural products
marine sponge
mass spectrometry
nuclear magnetic resonance
Siliquariaspongia japonica

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica",

abstract = "A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.",

keywords = "anti-leishmanial activity, aurantosides, marine natural products, marine sponge, mass spectrometry, nuclear magnetic resonance, Siliquariaspongia japonica",

author = "Yasumoto Oyadomari and Yasuyuki Goto and Keisuke Suganuma and Kawazu, {Shin Ichiro} and Becking, {Leontine E.} and Nobuhiro Fusetani and Yoichi Nakao",

year = "2024",

month = apr,

doi = "10.3390/md22040171",

language = "English",

volume = "22",

journal = "Marine Drugs",

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publisher = "MDPI",

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T1 - Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

AU - Oyadomari, Yasumoto

AU - Goto, Yasuyuki

AU - Suganuma, Keisuke

AU - Kawazu, Shin Ichiro

AU - Becking, Leontine E.

AU - Fusetani, Nobuhiro

AU - Nakao, Yoichi

PY - 2024/4

Y1 - 2024/4

N2 - A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.

AB - A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.

KW - anti-leishmanial activity

KW - aurantosides

KW - marine natural products

KW - marine sponge

KW - mass spectrometry

KW - nuclear magnetic resonance

KW - Siliquariaspongia japonica

U2 - 10.3390/md22040171

DO - 10.3390/md22040171

M3 - Article

C2 - 38667788

AN - SCOPUS:85191532938

SN - 1660-3397

VL - 22

JO - Marine Drugs

JF - Marine Drugs

IS - 4

M1 - 171

ER -

Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

Abstract

Keywords

UN SDGs

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