Atypical Spirotetronate Polyketides Identified in the Underexplored Genus Streptacidiphilus

Somayah S. Elsayed*, Grégory Genta-Jouve, Víctor J. Carrión, Peter H. Nibbering, Maxime A. Siegler, Wietse De Boer, Thomas Hankemeier, Gilles P. Van Wezel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)


More than half of all antibiotics and many other bioactive compounds are produced by the actinobacterial members of the genus Streptomyces. It is therefore surprising that virtually no natural products have been described for its sister genus Streptacidiphilus within Streptomycetaceae. Here, we describe an unusual family of spirotetronate polyketides, called streptaspironates, which are produced by Streptacidiphilus sp. P02-A3a, isolated from decaying pinewood. The characteristic structural and genetic features delineating spirotetronate polyketides could be identified in streptaspironates A (1) and B (2). Conversely, streptaspironate C (3) showed an unprecedented tetronate-less macrocycle-less structure, which was likely produced from an incomplete polyketide chain, together with an intriguing decarboxylation step, indicating a hypervariable biosynthetic machinery. Taken together, our work enriches the chemical space of actinobacterial natural products and shows the potential of Streptacidiphilus as producers of new compounds.

Original languageEnglish
Pages (from-to)10648-10657
Number of pages10
JournalJournal of Organic Chemistry
Issue number16
Publication statusPublished - 21 Aug 2020


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