Attenuating bacterial virulence by attenuating bacterial folate transport

A. Ingebritson; A. Neubauer; H.E. Smith; A. de Greeff

Attenuating bacterial virulence by attenuating bacterial folate transport

A. Ingebritson (Inventor), A. Neubauer (Inventor), H.E. Smith (Inventor), A. de Greeff (Inventor)

Bacteriology, Host Pathogen Interaction & Diagnostics

Research output: Patent

Abstract

The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. Provided is a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein the capacity has been reduced by functionally deleting folate transporter (FolT) function. Also provided is a method to reduce virulence of a bacterium comprising reducing the capacity of the bacterium to transport folate.

Original language	English
Patent number	WO2018089841
Priority date	11/11/16
Publication status	Published - 17 May 2018

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Attenuating bacterial virulence by attenuating bacterial folate transport",

abstract = "The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. Provided is a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein the capacity has been reduced by functionally deleting folate transporter (FolT) function. Also provided is a method to reduce virulence of a bacterium comprising reducing the capacity of the bacterium to transport folate.",

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AU - Neubauer, A.

AU - Smith, H.E.

AU - de Greeff, A.

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N2 - The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. Provided is a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein the capacity has been reduced by functionally deleting folate transporter (FolT) function. Also provided is a method to reduce virulence of a bacterium comprising reducing the capacity of the bacterium to transport folate.

AB - The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. Provided is a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein the capacity has been reduced by functionally deleting folate transporter (FolT) function. Also provided is a method to reduce virulence of a bacterium comprising reducing the capacity of the bacterium to transport folate.

M3 - Patent

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Attenuating bacterial virulence by attenuating bacterial folate transport

Abstract

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