Attenuating bacterial virulence by attenuating bacterial folate transport

A. Ingebritson (Inventor), A. Neubauer (Inventor), H.E. Smith (Inventor), A. de Greeff (Inventor)

Research output: PatentOther research output

Abstract

The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. Provided is a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein the capacity has been reduced by functionally deleting folate transporter (FolT) function. Also provided is a method to reduce virulence of a bacterium comprising reducing the capacity of the bacterium to transport folate.
LanguageEnglish
Patent numberWO2018089841
Priority date11/11/16
Publication statusPublished - 17 May 2018

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Folic Acid
Bacterial Vaccines
Virulence
Bacteria
Folic Acid Transporters
Infection
Streptococcus
Bacterial Infections
Swine
Vaccines

Cite this

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abstract = "The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. Provided is a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein the capacity has been reduced by functionally deleting folate transporter (FolT) function. Also provided is a method to reduce virulence of a bacterium comprising reducing the capacity of the bacterium to transport folate.",
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Attenuating bacterial virulence by attenuating bacterial folate transport. / Ingebritson, A. (Inventor); Neubauer, A. (Inventor); Smith, H.E. (Inventor); de Greeff, A. (Inventor).

Patent No.: WO2018089841.

Research output: PatentOther research output

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AU - Neubauer, A.

AU - Smith, H.E.

AU - de Greeff, A.

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N2 - The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. Provided is a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein the capacity has been reduced by functionally deleting folate transporter (FolT) function. Also provided is a method to reduce virulence of a bacterium comprising reducing the capacity of the bacterium to transport folate.

AB - The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. Provided is a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein the capacity has been reduced by functionally deleting folate transporter (FolT) function. Also provided is a method to reduce virulence of a bacterium comprising reducing the capacity of the bacterium to transport folate.

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Ingebritson A, Neubauer A, Smith HE, de Greeff A, inventors. Attenuating bacterial virulence by attenuating bacterial folate transport. WO2018089841. 2018 May 17.