Attenuating bacterial virulence by attenuating bacterial folate transport

A. Ingebritson (Inventor), A. Neubauer (Inventor), H.E. Smith (Inventor), A. de Greeff (Inventor)

Research output: PatentOther research output


The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. Provided is a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein the capacity has been reduced by functionally deleting folate transporter (FolT) function. Also provided is a method to reduce virulence of a bacterium comprising reducing the capacity of the bacterium to transport folate.
Original languageEnglish
Patent numberWO2018089841
Priority date11/11/16
Publication statusPublished - 17 May 2018

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