Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 154-158 |
| Journal | Experimental Gerontology |
| Volume | 106 |
| Early online date | 20 Feb 2018 |
| DOIs | |
| Publication status | Published - Jun 2018 |
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Attenuated strength gains during prolonged resistance exercise training in older adults with high inflammatory status. / Hangelbroek, R.W.J.; Knuiman, P.; Tieland, Michael; de Groot, C.P.G.M.
In: Experimental Gerontology, Vol. 106, 06.2018, p. 154-158.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Attenuated strength gains during prolonged resistance exercise training in older adults with high inflammatory status
AU - Hangelbroek, R.W.J.
AU - Knuiman, P.
AU - Tieland, Michael
AU - de Groot, C.P.G.M.
PY - 2018/6
Y1 - 2018/6
N2 - Objectives: Chronic systemic low grade inflammation is associated with the age-related loss of muscle mass. Resistance exercise has been suggested to reduce or lower chronic systemic low grade inflammation. However, systemic chronic low-grade inflammation may adversely affect the adaptive response to exercise training. We investigated the effect of resistance exercise training on systemic chronic low-grade inflammation in older adults. In addition, we studied the association between systemic chronic low-grade inflammation and the adaptive response to exercise training. Design/setting/participants: Frail and pre-frail older adults (61 subjects) performed 24 weeks of progressive resistance exercise training. Frailty was assessed using the Fried frailty criteria. Measurements: Lean body mass (DXA), strength (1RM), circulating levels of IL-1β, IL-6, IL-8 and TNF-α were measured prior to exercise training, after 12 weeks of training, and after 24 weeks of training. Results: Prolonged progressive resistance exercise training did not affect circulating levels of IL-6, IL-8 and TNF-α. However, exercise training led to a small but significant increase of 0.052 pg/mL in IL-1β. Higher circulating levels of TNF-α, IL-8 and IL-6 during the training period were negatively associated with strength gains for the leg press. A doubling of plasma TNF-α, IL-8 or IL-6 resulted in reduced strength gains for leg press with coefficients of −3.52, −3.42 and −1.54 respectively. High levels of circulating TNF-α were also associated with decreased strength gains for the leg extension (coefficient −1.50). Inflammatory cytokines did not appear to have an effect on gains in lean mass. Conclusion: Our findings suggest that increased levels of plasma cytokines (TNF-α, IL-6 and IL-8) are associated with lower strength gains during resistance exercise training.
AB - Objectives: Chronic systemic low grade inflammation is associated with the age-related loss of muscle mass. Resistance exercise has been suggested to reduce or lower chronic systemic low grade inflammation. However, systemic chronic low-grade inflammation may adversely affect the adaptive response to exercise training. We investigated the effect of resistance exercise training on systemic chronic low-grade inflammation in older adults. In addition, we studied the association between systemic chronic low-grade inflammation and the adaptive response to exercise training. Design/setting/participants: Frail and pre-frail older adults (61 subjects) performed 24 weeks of progressive resistance exercise training. Frailty was assessed using the Fried frailty criteria. Measurements: Lean body mass (DXA), strength (1RM), circulating levels of IL-1β, IL-6, IL-8 and TNF-α were measured prior to exercise training, after 12 weeks of training, and after 24 weeks of training. Results: Prolonged progressive resistance exercise training did not affect circulating levels of IL-6, IL-8 and TNF-α. However, exercise training led to a small but significant increase of 0.052 pg/mL in IL-1β. Higher circulating levels of TNF-α, IL-8 and IL-6 during the training period were negatively associated with strength gains for the leg press. A doubling of plasma TNF-α, IL-8 or IL-6 resulted in reduced strength gains for leg press with coefficients of −3.52, −3.42 and −1.54 respectively. High levels of circulating TNF-α were also associated with decreased strength gains for the leg extension (coefficient −1.50). Inflammatory cytokines did not appear to have an effect on gains in lean mass. Conclusion: Our findings suggest that increased levels of plasma cytokines (TNF-α, IL-6 and IL-8) are associated with lower strength gains during resistance exercise training.
U2 - 10.1016/j.exger.2018.02.008
DO - 10.1016/j.exger.2018.02.008
M3 - Article
VL - 106
SP - 154
EP - 158
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
ER -