ATHON NDL-PCB effect database—A tool to facilitate the cumulative risk assessment of NDL-PCBs

E. Wosterholm; J. Boix; H.M. Miettinen; R. Roos; E.C. Antunes Fernandes; R. Westerink; M. van Duursen; M. Stenberg; S. Correia Carreira; M. Machala; I. Silins; U. Stenius; K. Halldin; A. Hanberg; H. Hakansson

doi:10.1016/j.toxlet.2009.06.467

Abstract

ATHON—Assessing the toxicity and hazard of non-dioxin like PCBs present in food—is an FP6 project designed to study the biological effects of non-dioxin like (NDL) PCBs. ATHON has developed a toxicological effect database for NDL-PCBs. During the period March 2008 to February 2009, 138 references defined as concerning effects of NDL-PCBs were identified in literature. After exclusion of 37 Arochlor papers, about 20% of the remaining 101 references describe in vitro studies while in vivo and epidemiology studies are described in 30% of the references each. 15% of the references were reviews and were only included if they contained original data. The references were also divided into the ATHON main areas, i.e. neurotoxicity, reproduction/development, liver/cancer, and endocrinology, with approximately one fifth of the references classified into each effect sub-category. A text mining technology was used to rank and classify references older than March 2008 based on the evidence they contain. As ATHON progresses, the database will be updated with data generated within the project using ultra pure NDL-PCBs as well as with available data from other recent EU projects. The anticipated outcome of the effect database is to identify NDL-PCB specific effect biomarkers and mechanisms of action and to further develop the toxicity-based NDL-PCB classification strategy. The information in the database combined with the unique ATHON data will be used for an NDL-PCB monograph intended as a basis for discussions on NDL-PCB guidance values.

Original language	English
Title of host publication	Abstracts of the 46th Congress of the European Societies of Toxicology
Pages	S244
Volume	189
DOIs	https://doi.org/10.1016/j.toxlet.2009.06.467
Publication status	Published - 2009
Event	46th Congress of the European Societies of Toxicology - Duration: 13 Sept 2009 → 16 Sept 2009

Conference/symposium

Conference/symposium	46th Congress of the European Societies of Toxicology
Period	13/09/09 → 16/09/09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.toxlet.2009.06.467

Cite this

Wosterholm, E., Boix, J., Miettinen, H. M., Roos, R., Antunes Fernandes, E. C., Westerink, R., van Duursen, M., Stenberg, M., Correia Carreira, S., Machala, M., Silins, I., Stenius, U., Halldin, K., Hanberg, A., & Hakansson, H. (2009). ATHON NDL-PCB effect database—A tool to facilitate the cumulative risk assessment of NDL-PCBs. In Abstracts of the 46th Congress of the European Societies of Toxicology (Vol. 189, pp. S244) https://doi.org/10.1016/j.toxlet.2009.06.467

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title = "ATHON NDL-PCB effect database—A tool to facilitate the cumulative risk assessment of NDL-PCBs",

abstract = "ATHON—Assessing the toxicity and hazard of non-dioxin like PCBs present in food—is an FP6 project designed to study the biological effects of non-dioxin like (NDL) PCBs. ATHON has developed a toxicological effect database for NDL-PCBs. During the period March 2008 to February 2009, 138 references defined as concerning effects of NDL-PCBs were identified in literature. After exclusion of 37 Arochlor papers, about 20% of the remaining 101 references describe in vitro studies while in vivo and epidemiology studies are described in 30% of the references each. 15% of the references were reviews and were only included if they contained original data. The references were also divided into the ATHON main areas, i.e. neurotoxicity, reproduction/development, liver/cancer, and endocrinology, with approximately one fifth of the references classified into each effect sub-category. A text mining technology was used to rank and classify references older than March 2008 based on the evidence they contain. As ATHON progresses, the database will be updated with data generated within the project using ultra pure NDL-PCBs as well as with available data from other recent EU projects. The anticipated outcome of the effect database is to identify NDL-PCB specific effect biomarkers and mechanisms of action and to further develop the toxicity-based NDL-PCB classification strategy. The information in the database combined with the unique ATHON data will be used for an NDL-PCB monograph intended as a basis for discussions on NDL-PCB guidance values.",

author = "E. Wosterholm and J. Boix and H.M. Miettinen and R. Roos and {Antunes Fernandes}, E.C. and R. Westerink and {van Duursen}, M. and M. Stenberg and {Correia Carreira}, S. and M. Machala and I. Silins and U. Stenius and K. Halldin and A. Hanberg and H. Hakansson",

year = "2009",

doi = "10.1016/j.toxlet.2009.06.467",

language = "English",

volume = "189",

pages = "S244",

booktitle = "Abstracts of the 46th Congress of the European Societies of Toxicology",

note = "46th Congress of the European Societies of Toxicology ; Conference date: 13-09-2009 Through 16-09-2009",

}

Wosterholm, E, Boix, J, Miettinen, HM, Roos, R, Antunes Fernandes, EC, Westerink, R, van Duursen, M, Stenberg, M, Correia Carreira, S, Machala, M, Silins, I, Stenius, U, Halldin, K, Hanberg, A & Hakansson, H 2009, ATHON NDL-PCB effect database—A tool to facilitate the cumulative risk assessment of NDL-PCBs. in Abstracts of the 46th Congress of the European Societies of Toxicology. vol. 189, pp. S244, 46th Congress of the European Societies of Toxicology, 13/09/09. https://doi.org/10.1016/j.toxlet.2009.06.467

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AU - Wosterholm, E.

AU - Boix, J.

AU - Miettinen, H.M.

AU - Roos, R.

AU - Antunes Fernandes, E.C.

AU - Westerink, R.

AU - van Duursen, M.

AU - Stenberg, M.

AU - Correia Carreira, S.

AU - Machala, M.

AU - Silins, I.

AU - Stenius, U.

AU - Halldin, K.

AU - Hanberg, A.

AU - Hakansson, H.

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DO - 10.1016/j.toxlet.2009.06.467

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BT - Abstracts of the 46th Congress of the European Societies of Toxicology

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