Associations of AD biomarkers and cognitive performance with nutritional status: The NUDAD project

Astrid S. Doorduijn, Marjolein Visser, Ondine van de Rest, Maartje I. Kester, Francisca A. de Leeuw, Sanne Boesveldt, Jay L.P. Fieldhouse, Ellen G.H.M. van den Heuvel, Charlotte E. Teunissen, Philip Scheltens, Wiesje M. van der Flier, Marian A.E. de van der Schueren

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

As malnutrition is common in patients with Alzheimer’s disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 participants, of which 198 patients had AD, 135 patients had MCI and 219 controls. We assessed nutritional status (mini nutritional assessment (MNA)) and body composition (body mass index (BMI), fat-free mass (FFM) and waist circumference). Linear regression analyses (adjusted for age, gender and education where appropriate) were applied to test associations of AD biomarkers and cognitive performance on five domains with nutritional parameters (dependent). Patients with MCI and AD had a lower BMI and MNA score than controls. Worse performance in all cognitive domains was associated with lower MNA score, but not with body composition. AD biomarkers were associated with MNA score, BMI and waist circumference, and associations with MNA score remained after adjustment for cognitive performance. Both AD biomarkers and cognitive performance were associated with nutritional status, associations with AD biomarkers remained after adjustment for cognition. Our data suggest that malnutrition is not only related to impaired cognition but also to AD pathology.

LanguageEnglish
Article number1161
JournalNutrients
Volume11
Issue number5
DOIs
Publication statusPublished - 23 May 2019

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Nutritional Status
nutrition assessment
cognition
nutritional status
biomarkers
Alzheimer Disease
Biomarkers
Nutrition Assessment
body composition
body mass index
Body Composition
waist circumference
malnutrition
Body Mass Index
Waist Circumference
Malnutrition
Cognition
education
gender
lipids

Keywords

  • Alzheimer’s disease
  • Body composition
  • Malnutrition
  • Mild cognitive impairment
  • Older adults
  • Subjective cognitive decline

Cite this

Doorduijn, Astrid S. ; Visser, Marjolein ; van de Rest, Ondine ; Kester, Maartje I. ; de Leeuw, Francisca A. ; Boesveldt, Sanne ; Fieldhouse, Jay L.P. ; van den Heuvel, Ellen G.H.M. ; Teunissen, Charlotte E. ; Scheltens, Philip ; van der Flier, Wiesje M. ; de van der Schueren, Marian A.E. / Associations of AD biomarkers and cognitive performance with nutritional status: The NUDAD project. In: Nutrients. 2019 ; Vol. 11, No. 5.
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abstract = "As malnutrition is common in patients with Alzheimer’s disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 participants, of which 198 patients had AD, 135 patients had MCI and 219 controls. We assessed nutritional status (mini nutritional assessment (MNA)) and body composition (body mass index (BMI), fat-free mass (FFM) and waist circumference). Linear regression analyses (adjusted for age, gender and education where appropriate) were applied to test associations of AD biomarkers and cognitive performance on five domains with nutritional parameters (dependent). Patients with MCI and AD had a lower BMI and MNA score than controls. Worse performance in all cognitive domains was associated with lower MNA score, but not with body composition. AD biomarkers were associated with MNA score, BMI and waist circumference, and associations with MNA score remained after adjustment for cognitive performance. Both AD biomarkers and cognitive performance were associated with nutritional status, associations with AD biomarkers remained after adjustment for cognition. Our data suggest that malnutrition is not only related to impaired cognition but also to AD pathology.",
keywords = "Alzheimer’s disease, Body composition, Malnutrition, Mild cognitive impairment, Older adults, Subjective cognitive decline",
author = "Doorduijn, {Astrid S.} and Marjolein Visser and {van de Rest}, Ondine and Kester, {Maartje I.} and {de Leeuw}, {Francisca A.} and Sanne Boesveldt and Fieldhouse, {Jay L.P.} and {van den Heuvel}, {Ellen G.H.M.} and Teunissen, {Charlotte E.} and Philip Scheltens and {van der Flier}, {Wiesje M.} and {de van der Schueren}, {Marian A.E.}",
year = "2019",
month = "5",
day = "23",
doi = "10.3390/nu11051161",
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Doorduijn, AS, Visser, M, van de Rest, O, Kester, MI, de Leeuw, FA, Boesveldt, S, Fieldhouse, JLP, van den Heuvel, EGHM, Teunissen, CE, Scheltens, P, van der Flier, WM & de van der Schueren, MAE 2019, 'Associations of AD biomarkers and cognitive performance with nutritional status: The NUDAD project', Nutrients, vol. 11, no. 5, 1161. https://doi.org/10.3390/nu11051161

Associations of AD biomarkers and cognitive performance with nutritional status: The NUDAD project. / Doorduijn, Astrid S.; Visser, Marjolein; van de Rest, Ondine; Kester, Maartje I.; de Leeuw, Francisca A.; Boesveldt, Sanne; Fieldhouse, Jay L.P.; van den Heuvel, Ellen G.H.M.; Teunissen, Charlotte E.; Scheltens, Philip; van der Flier, Wiesje M.; de van der Schueren, Marian A.E.

In: Nutrients, Vol. 11, No. 5, 1161, 23.05.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Associations of AD biomarkers and cognitive performance with nutritional status: The NUDAD project

AU - Doorduijn, Astrid S.

AU - Visser, Marjolein

AU - van de Rest, Ondine

AU - Kester, Maartje I.

AU - de Leeuw, Francisca A.

AU - Boesveldt, Sanne

AU - Fieldhouse, Jay L.P.

AU - van den Heuvel, Ellen G.H.M.

AU - Teunissen, Charlotte E.

AU - Scheltens, Philip

AU - van der Flier, Wiesje M.

AU - de van der Schueren, Marian A.E.

PY - 2019/5/23

Y1 - 2019/5/23

N2 - As malnutrition is common in patients with Alzheimer’s disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 participants, of which 198 patients had AD, 135 patients had MCI and 219 controls. We assessed nutritional status (mini nutritional assessment (MNA)) and body composition (body mass index (BMI), fat-free mass (FFM) and waist circumference). Linear regression analyses (adjusted for age, gender and education where appropriate) were applied to test associations of AD biomarkers and cognitive performance on five domains with nutritional parameters (dependent). Patients with MCI and AD had a lower BMI and MNA score than controls. Worse performance in all cognitive domains was associated with lower MNA score, but not with body composition. AD biomarkers were associated with MNA score, BMI and waist circumference, and associations with MNA score remained after adjustment for cognitive performance. Both AD biomarkers and cognitive performance were associated with nutritional status, associations with AD biomarkers remained after adjustment for cognition. Our data suggest that malnutrition is not only related to impaired cognition but also to AD pathology.

AB - As malnutrition is common in patients with Alzheimer’s disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 participants, of which 198 patients had AD, 135 patients had MCI and 219 controls. We assessed nutritional status (mini nutritional assessment (MNA)) and body composition (body mass index (BMI), fat-free mass (FFM) and waist circumference). Linear regression analyses (adjusted for age, gender and education where appropriate) were applied to test associations of AD biomarkers and cognitive performance on five domains with nutritional parameters (dependent). Patients with MCI and AD had a lower BMI and MNA score than controls. Worse performance in all cognitive domains was associated with lower MNA score, but not with body composition. AD biomarkers were associated with MNA score, BMI and waist circumference, and associations with MNA score remained after adjustment for cognitive performance. Both AD biomarkers and cognitive performance were associated with nutritional status, associations with AD biomarkers remained after adjustment for cognition. Our data suggest that malnutrition is not only related to impaired cognition but also to AD pathology.

KW - Alzheimer’s disease

KW - Body composition

KW - Malnutrition

KW - Mild cognitive impairment

KW - Older adults

KW - Subjective cognitive decline

U2 - 10.3390/nu11051161

DO - 10.3390/nu11051161

M3 - Article

VL - 11

JO - Nutrients

T2 - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 5

M1 - 1161

ER -