Associations between plasma branched-chain amino acids, β-aminoisobutyric acid and body composition

Annemarie Rietman*, Takara L. Stanley, Clary Clish, Vamsi Mootha, Marco Mensink, Steven K. Grinspoon, Hideo Makimura

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

Plasma branched-chain amino acids (BCAA) are elevated in obesity and associated with increased cardiometabolic risk. β-Aminoisobutyric acid (B-AIBA), a recently identified small molecule metabolite, is associated with decreased cardiometabolic risk. Therefore, we investigated the association of BCAA and B-AIBA with each other and with detailed body composition parameters, including abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). A cross-sectional study was carried out with lean (n 15) and obese (n 33) men and women. Detailed metabolic evaluations, including measures of body composition, insulin sensitivity and plasma metabolomics were completed. Plasma BCAA were higher (1·6 (SE 0·08) (×107) v. 1·3 (SE 0·06) (×107) arbitrary units; P = 0·005) in obese v. lean subjects. BCAA were positively associated with VAT (R 0·49; P = 0·0006) and trended to an association with SAT (R 0·29; P = 0·052). The association between BCAA and VAT, but not SAT, Remained significant after controlling for age, sex and race on multivariate modelling (P < 0·05). BCAA were also associated with parameters of insulin sensitivity (Matsuda index: R −0·50, P = 0·0004; glucose AUC: R 0·53, P < 0·001). BCAA were not associated with B-AIBA (R −0·04; P = 0·79). B-AIBA was negatively associated with SAT (R −0·37; P = 0·01) but only trended to an association with VAT (R 0·27; P = 0·07). However, neither relationship Remained significant after multivariate modelling (P > 0·05). Plasma B-AIBA was associated with parameters of insulin sensitivity (Matsuda index R 0·36, P = 0·01; glucose AUC: R −0·30, P = 0·04). Plasma BCAA levels were positively correlated with VAT and markers of insulin resistance. The results suggest a possible complex role of adipose tissue in BCAA homeostasis and insulin resistance.

Original languageEnglish
Article numbere6
JournalJournal of Nutritional Science
Volume5
DOIs
Publication statusPublished - 3 Feb 2016

Fingerprint

Aminoisobutyric Acids
Branched Chain Amino Acids
branched chain amino acids
Body Composition
adipose tissue
body composition
Intra-Abdominal Fat
acids
Insulin Resistance
Subcutaneous Fat
insulin resistance
Abdominal Fat
Metabolomics
risk reduction
metabolomics
Area Under Curve
Adipose Tissue
cross-sectional studies
Homeostasis
Obesity

Keywords

  • Branched-chain amino acids
  • Lean body mass
  • Metabolomics
  • Subcutaneous adipose tissue
  • Visceral adiposity
  • β-aminoisobutyric acid

Cite this

Rietman, Annemarie ; Stanley, Takara L. ; Clish, Clary ; Mootha, Vamsi ; Mensink, Marco ; Grinspoon, Steven K. ; Makimura, Hideo. / Associations between plasma branched-chain amino acids, β-aminoisobutyric acid and body composition. In: Journal of Nutritional Science. 2016 ; Vol. 5.
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abstract = "Plasma branched-chain amino acids (BCAA) are elevated in obesity and associated with increased cardiometabolic risk. β-Aminoisobutyric acid (B-AIBA), a recently identified small molecule metabolite, is associated with decreased cardiometabolic risk. Therefore, we investigated the association of BCAA and B-AIBA with each other and with detailed body composition parameters, including abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). A cross-sectional study was carried out with lean (n 15) and obese (n 33) men and women. Detailed metabolic evaluations, including measures of body composition, insulin sensitivity and plasma metabolomics were completed. Plasma BCAA were higher (1·6 (SE 0·08) (×107) v. 1·3 (SE 0·06) (×107) arbitrary units; P = 0·005) in obese v. lean subjects. BCAA were positively associated with VAT (R 0·49; P = 0·0006) and trended to an association with SAT (R 0·29; P = 0·052). The association between BCAA and VAT, but not SAT, Remained significant after controlling for age, sex and race on multivariate modelling (P < 0·05). BCAA were also associated with parameters of insulin sensitivity (Matsuda index: R −0·50, P = 0·0004; glucose AUC: R 0·53, P < 0·001). BCAA were not associated with B-AIBA (R −0·04; P = 0·79). B-AIBA was negatively associated with SAT (R −0·37; P = 0·01) but only trended to an association with VAT (R 0·27; P = 0·07). However, neither relationship Remained significant after multivariate modelling (P > 0·05). Plasma B-AIBA was associated with parameters of insulin sensitivity (Matsuda index R 0·36, P = 0·01; glucose AUC: R −0·30, P = 0·04). Plasma BCAA levels were positively correlated with VAT and markers of insulin resistance. The results suggest a possible complex role of adipose tissue in BCAA homeostasis and insulin resistance.",
keywords = "Branched-chain amino acids, Lean body mass, Metabolomics, Subcutaneous adipose tissue, Visceral adiposity, β-aminoisobutyric acid",
author = "Annemarie Rietman and Stanley, {Takara L.} and Clary Clish and Vamsi Mootha and Marco Mensink and Grinspoon, {Steven K.} and Hideo Makimura",
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Associations between plasma branched-chain amino acids, β-aminoisobutyric acid and body composition. / Rietman, Annemarie; Stanley, Takara L.; Clish, Clary; Mootha, Vamsi; Mensink, Marco; Grinspoon, Steven K.; Makimura, Hideo.

In: Journal of Nutritional Science, Vol. 5, e6, 03.02.2016.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Associations between plasma branched-chain amino acids, β-aminoisobutyric acid and body composition

AU - Rietman, Annemarie

AU - Stanley, Takara L.

AU - Clish, Clary

AU - Mootha, Vamsi

AU - Mensink, Marco

AU - Grinspoon, Steven K.

AU - Makimura, Hideo

PY - 2016/2/3

Y1 - 2016/2/3

N2 - Plasma branched-chain amino acids (BCAA) are elevated in obesity and associated with increased cardiometabolic risk. β-Aminoisobutyric acid (B-AIBA), a recently identified small molecule metabolite, is associated with decreased cardiometabolic risk. Therefore, we investigated the association of BCAA and B-AIBA with each other and with detailed body composition parameters, including abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). A cross-sectional study was carried out with lean (n 15) and obese (n 33) men and women. Detailed metabolic evaluations, including measures of body composition, insulin sensitivity and plasma metabolomics were completed. Plasma BCAA were higher (1·6 (SE 0·08) (×107) v. 1·3 (SE 0·06) (×107) arbitrary units; P = 0·005) in obese v. lean subjects. BCAA were positively associated with VAT (R 0·49; P = 0·0006) and trended to an association with SAT (R 0·29; P = 0·052). The association between BCAA and VAT, but not SAT, Remained significant after controlling for age, sex and race on multivariate modelling (P < 0·05). BCAA were also associated with parameters of insulin sensitivity (Matsuda index: R −0·50, P = 0·0004; glucose AUC: R 0·53, P < 0·001). BCAA were not associated with B-AIBA (R −0·04; P = 0·79). B-AIBA was negatively associated with SAT (R −0·37; P = 0·01) but only trended to an association with VAT (R 0·27; P = 0·07). However, neither relationship Remained significant after multivariate modelling (P > 0·05). Plasma B-AIBA was associated with parameters of insulin sensitivity (Matsuda index R 0·36, P = 0·01; glucose AUC: R −0·30, P = 0·04). Plasma BCAA levels were positively correlated with VAT and markers of insulin resistance. The results suggest a possible complex role of adipose tissue in BCAA homeostasis and insulin resistance.

AB - Plasma branched-chain amino acids (BCAA) are elevated in obesity and associated with increased cardiometabolic risk. β-Aminoisobutyric acid (B-AIBA), a recently identified small molecule metabolite, is associated with decreased cardiometabolic risk. Therefore, we investigated the association of BCAA and B-AIBA with each other and with detailed body composition parameters, including abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). A cross-sectional study was carried out with lean (n 15) and obese (n 33) men and women. Detailed metabolic evaluations, including measures of body composition, insulin sensitivity and plasma metabolomics were completed. Plasma BCAA were higher (1·6 (SE 0·08) (×107) v. 1·3 (SE 0·06) (×107) arbitrary units; P = 0·005) in obese v. lean subjects. BCAA were positively associated with VAT (R 0·49; P = 0·0006) and trended to an association with SAT (R 0·29; P = 0·052). The association between BCAA and VAT, but not SAT, Remained significant after controlling for age, sex and race on multivariate modelling (P < 0·05). BCAA were also associated with parameters of insulin sensitivity (Matsuda index: R −0·50, P = 0·0004; glucose AUC: R 0·53, P < 0·001). BCAA were not associated with B-AIBA (R −0·04; P = 0·79). B-AIBA was negatively associated with SAT (R −0·37; P = 0·01) but only trended to an association with VAT (R 0·27; P = 0·07). However, neither relationship Remained significant after multivariate modelling (P > 0·05). Plasma B-AIBA was associated with parameters of insulin sensitivity (Matsuda index R 0·36, P = 0·01; glucose AUC: R −0·30, P = 0·04). Plasma BCAA levels were positively correlated with VAT and markers of insulin resistance. The results suggest a possible complex role of adipose tissue in BCAA homeostasis and insulin resistance.

KW - Branched-chain amino acids

KW - Lean body mass

KW - Metabolomics

KW - Subcutaneous adipose tissue

KW - Visceral adiposity

KW - β-aminoisobutyric acid

U2 - 10.1017/jns.2015.37

DO - 10.1017/jns.2015.37

M3 - Article

VL - 5

JO - Journal of Nutritional Science

JF - Journal of Nutritional Science

SN - 2048-6790

M1 - e6

ER -