Association of Habitual Preoperative Dietary Fiber Intake with Complications after Colorectal Cancer Surgery

Dieuwertje E. Kok*, Melissa N.N. Arron, Tess Huibregtse, Flip M. Kruyt, Dirk Jan Bac, Henk K. Van Halteren, Ewout A. Kouwenhoven, Evertine Wesselink, Renate M. Winkels, Moniek Van Zutphen, Fränzel J.B. Van Duijnhoven, Johannes H.W. De Wilt, Ellen Kampman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Importance: Postoperative complications are associated with increased morbidity and mortality among patients with colorectal cancer. As a modifiable factor associated with gut health, dietary fiber intake is of interest with regard to the risk of complications after surgery for colorectal cancer. Objective: To examine the association between preoperative dietary fiber intake and risk of complications after surgery for colorectal cancer. Design, Setting, and Participants: This cohort study used data from the Colorectal Longitudinal, Observational Study on Nutritional and Lifestyle Factors (COLON) study, which recruited adult patients with colorectal cancer at any stage at diagnosis from 11 hospitals in the Netherlands between August 2010 and December 2017. The present study included patients with stage I to IV colorectal cancer who underwent elective abdominal surgery. Data were analyzed between December 2019 and September 2020. Exposures: Habitual dietary fiber intake was assessed at diagnosis using a 204-item food frequency questionnaire. Main Outcomes and Measures: Any complications, surgical complications, and anastomotic leakage occurring during the 30 days after surgery for colorectal cancer. The association between fiber intake and risk of postoperative complications was assessed using logistic regression analyses. Additional analyses stratified by sex, tumor location, and fiber source were performed. Results: Among the 1399 patients included in the analysis, the median age at inclusion was 66 years (interquartile range, 61-72 years) and 896 (64%) were men. Any complications occurred in 397 patients (28%), and surgical complications occurred in 235 patients (17%). Of 1237 patients with an anastomosis, 67 (5%) experienced anastomotic leakage. Higher dietary fiber intake (per 10 g per day) was associated with a lower risk of any complications (odds ratio [OR], 0.75; 95% CI, 0.62-0.92) and surgical complications (OR, 0.76; 95% CI, 0.60-0.97), whereas no association with anastomotic leakage was found (OR, 0.97; 95% CI, 0.66-1.43). Among women, higher dietary intake was associated with any complications (OR, 0.64; 95% CI, 0.44-0.94), whereas there was no association among men (OR, 0.79; 95% CI, 0.63-1.01). Fiber intake from vegetables (per 1 g per day) was inversely associated with any (OR, 0.90; 95% CI, 0.83-0.99) and surgical (OR, 0.87; 95% CI, 0.78-0.97) complications. Conclusions and Relevance: In this cohort study, higher habitual dietary fiber intake before surgery was associated with a lower risk of postoperative complications among patients with colorectal cancer. The findings suggest that improving preoperative dietary fiber intake may be considered in future prehabilitation programs for patients undergoing surgery for colorectal cancer..

Original languageEnglish
Article number827
JournalJAMA Surgery
Volume156
Issue number9
Early online date16 Jun 2021
DOIs
Publication statusPublished - 2021

Fingerprint

Dive into the research topics of 'Association of Habitual Preoperative Dietary Fiber Intake with Complications after Colorectal Cancer Surgery'. Together they form a unique fingerprint.

Cite this