TY - JOUR
T1 - Association between vitamin B12 intake and EURRECA’s prioritized biomarkers of vitamin B12 in young populations: a systematic review
AU - Iglesia, I.
AU - Dhonukshe-Rutten, R.A.M.
AU - Bel-Serrat, S.
AU - Doets, E.L.
AU - Cavelaars, A.J.E.M.
AU - van 't Veer, P.
AU - Nissenshohn, M.
AU - Benetou, V.
AU - Hermoso, M.
AU - Berti, C.
AU - de Groot, C.P.G.M.
AU - Moreno, L.A.
PY - 2013
Y1 - 2013
N2 - Objective To review evidence on the associations between vitamin B12 intake and its biomarkers, vitamin B12 intake and its functional health outcomes, and vitamin B12 biomarkers and functional health outcomes.
Design A systematic review was conducted by searching electronic databases, until January 2012, using a standardized strategy developed in the EURRECA network. Relevant articles were screened and sorted based on title and abstract, then based on full text, and finally included if they met inclusion criteria. A total of sixteen articles were included in the review.
Setting Articles covered four continents: America (n 4), Europe (n 8), Africa (n 1) and Asia (n 3).
Subjects Population groups included healthy infants, children and adolescents, and pregnant and lactating women.
Results From the total number of 5815 papers retrieved from the initial search, only sixteen were eligible according to the inclusion criteria: five for infants, five for children and adolescents, and six for pregnant and lactating women.
Conclusions Only one main conclusion could be extracted from this scarce number of references: a positive association between vitamin B12 intake and serum vitamin B12 in the infant group. Other associations were not reported in the eligible papers or the results were not provided in a consistent manner. The low number of papers that could be included in our systematic review is probably due to the attention that is currently given to research on vitamin B12 in elderly people. Our observations in the current systematic review justify the idea of performing well-designed studies on vitamin B12 in young populations.
AB - Objective To review evidence on the associations between vitamin B12 intake and its biomarkers, vitamin B12 intake and its functional health outcomes, and vitamin B12 biomarkers and functional health outcomes.
Design A systematic review was conducted by searching electronic databases, until January 2012, using a standardized strategy developed in the EURRECA network. Relevant articles were screened and sorted based on title and abstract, then based on full text, and finally included if they met inclusion criteria. A total of sixteen articles were included in the review.
Setting Articles covered four continents: America (n 4), Europe (n 8), Africa (n 1) and Asia (n 3).
Subjects Population groups included healthy infants, children and adolescents, and pregnant and lactating women.
Results From the total number of 5815 papers retrieved from the initial search, only sixteen were eligible according to the inclusion criteria: five for infants, five for children and adolescents, and six for pregnant and lactating women.
Conclusions Only one main conclusion could be extracted from this scarce number of references: a positive association between vitamin B12 intake and serum vitamin B12 in the infant group. Other associations were not reported in the eligible papers or the results were not provided in a consistent manner. The low number of papers that could be included in our systematic review is probably due to the attention that is currently given to research on vitamin B12 in elderly people. Our observations in the current systematic review justify the idea of performing well-designed studies on vitamin B12 in young populations.
KW - neural-tube defects
KW - plasma homocysteine concentrations
KW - nutrient intake values
KW - maternal serum folate
KW - birth-weight infants
KW - early-pregnancy loss
KW - folic-acid
KW - micronutrient status
KW - cobalamin status
KW - school-children
U2 - 10.1017/S1368980012003953
DO - 10.1017/S1368980012003953
M3 - Article
SN - 1368-9800
VL - 16
SP - 1843
EP - 1860
JO - Public Health Nutrition
JF - Public Health Nutrition
IS - 10
ER -
