Assessing spatial resolution, acquisition time and signal-to-noise ratio for commercial microimaging systems at 14.1, 17.6 and 22.3 T

Julia R. Krug*, Remco van Schadewijk, Frank J. Vergeldt, Andrew G. Webb, Huub J.M. de Groot, A. Alia, Henk Van As, Aldrik H. Velders

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

This work provides a systematic comparison of the signal-to-noise ratio (SNR), spatial resolution, acquisition time and metabolite limits-of-detection for magnetic resonance microscopy and spectroscopy at three different magnetic field strengths of 14.1 T, 17.6 T and 22.3 T (the highest currently available for imaging), utilizing commercially available hardware. We find an SNR increase of a factor 5.9 going from 14.1 T to 22.3 T using 5 mm radiofrequency (saddle and birdcage) coils, which results in a 24-fold acceleration in acquisition time and deviates from the theoretically expected increase of factor 2.2 due to differences in hardware. This underlines the importance of not only the magnetic field strengths but also hardware optimization. In addition, using a home-built 1.5 mm solenoid coil, we can achieve an isotropic resolution of (5.5 µm)3 over a field-of-view of 1.58 mm × 1.05 mm × 1.05 mm with an SNR of 12:1 using 44 signal averages in 58 h 34 min acquisition time at 22.3 T. In light of these results, we discuss future perspectives for ultra-high field Magnetic Resonance Microscopy and Spectroscopy.

Original languageEnglish
Article number106770
JournalJournal of Magnetic Resonance
Volume316
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Limit of detection
  • Magnetic resonance microscopy
  • Signal-to-noise ratio
  • Ultra-high field strength

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