Aspergillus oryzae in solid-state and submerged fermentations. Progress report on a multi-disciplinary project

R. te Biesebeke, G. Ruijter, Y.S.P. Rahardjo, M.J. Hoogschagen, M. Heerikhuisen, A. Levin, K.G.A. van Driel, M.A.I. Schutyser, J. Dijksterhuis, Yang Yang Zhu, F.J. Weber, W.M. de Vos, K.A. van den Hondel, A. Rinzema, P.J. Punt

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Abstract

We report the progress of a multi-disciplinary research project on solid-state fermentation (SSF) of the filamentous fungus Aspergillus oryzae. The molecular and physiological aspects of the fungus in submerged fermentation (SmF) and SSF are compared and we observe a number of differences correlated with the different growth conditions. First, the aerial hyphae which occur only in SSFs are mainly responsible for oxygen uptake. Second, SSF is characterised by gradients in temperature, water activity and nutrient concentration, and inside the hyphae different polyols are accumulating. Third, pelleted growth in SmF and mycelial growth in SSF show different gene expression and protein secretion patterns. With this approach we aim to expand our knowledge of mechanisms of fungal growth on solid substrates and to exploit the biotechnological applications
Original languageEnglish
Pages (from-to)245-248
JournalFEMS Yeast Research
Volume2
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • encoding gene glab
  • fungal growth
  • culture
  • expression
  • limitation
  • oxygen

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